Table 3

Haemorheological behaviour during repeated treadmill exercise test in 15 patients with stage II peripheral vascular disease compared with 15 matched placebo controls before and after Clopidogrel treatment

1st day2nd day5th day
ClopidogrelPlaceboClopidogrelPlaceboClopidogrelPlacebo
Whole blood viscosity refers to the ratio of low shear blood viscosity at haematocrit corrected to 45% to plasma viscosity; leucocyte activation refers to leucocytes with pseudopodia and/or cytoplasmic irregularities; leucocyte filterability rate refers to the pressure ratio of cell suspension to buffer after 6 minutes of filtration.
Intragroup analysis: *p<0.01 v baseline; †p<0.01 v 1st day, ‡p<0.01 v 2nd day; intergroup analysis: §p<0.01 v placebo group. Values are expressed as mean (SD).
Whole blood viscosity (cP) (shear rate 0.94/s)
    Baseline26.5 (1.0)26.3 (1.1)26.6 (1.0)26.7 (1.6)26.4 (1.0)26.4 (1.0)
    Peak29.4 (1.1)*29.2 (1.3)*29.5 (1.1)*29.6 (1.2)*26.4 (1.1)†‡§29.5 (1.3)*
Leucoyte activation (%)
    Baseline10.5 (1.8)11.1 (2.1)10.7 (1.2)10.7 (2.2)11.1 (1.9)10.9 (2.0)
    Peak15.9 (2.5)*16.7 (1.9)*16.1 (2.5)*16.3 (2.2)*11.6 (1.9)†‡§16.5 (2.1)*
Leucoyte filterability rate (P/P)
    Baseline6.1 (0.5)6.0 (0.4)6.0 (0.4)6.1 (0.4)6.2 (0.4)6.1 (0.5)
    Peak7.8 (0.5)*7.9 (0.4)*7.6 (0.8)*7.9 (0.3)*6.2 (0.6)†‡§7.7 (0.3)*
Soluble P-selectin (ng/ml)
    Baseline366 (12)366 (19)362 (11)371 (14)359 (16)359 (16)
    Peak405 (14)*404 (15)*356 (25)†§411 (11)*353 (23)†‡§401 (13)*
Platelet count (×109/l)
    Baseline248 (10)235 (17)253 (10)242 (15)244 (23)239 (22)
    Peak278 (15)*270 (14)*281 (16)*273 (13)*271 (20)*275 (19)*
Total leucocyte count (×109/l)
    Baseline7.8 (0.5)7.6 (0.4)8.0 (0.6)7.8 (0.5)7.9 (0.5)7.9 (0.4)
    Peak9.4 (0.8)*9.2 (0.8)*9.7 (0.8)*9.5 (1.0)*9.7 (1.0)*9.6 (0.8)*