Features used: number of cases where 50% or more of all pathologists correctly identifying each case selected feature as important and likelihood ratios (LR) for features distinguishing between Crohn’s disease (CD) and ulcerative colitis (UC)
| CD (n=12) | UC (n=12) | |||
|---|---|---|---|---|
| Number of cases | LR | Number of cases | LR | |
| Architecture | ||||
| (1) Focal crypt architectural irregularity | 8 | 1.7 | 2 | 0.6 |
| (2) Diffuse crypt architectural irregularity | 1 | 0.3 | 11 | 3.4 |
| (3) Reduced crypt numbers/atrophy | 2 | 0.3 | 9 | 2.9 |
| Chronic inflammation | ||||
| (4) Focal or patchy | 8 | 3.3 | 1 | 0.3 |
| (5) Basal plasma cells | 5 | 0.4 | 12 | 2.3 |
| (6) Diffuse superficial inflammation | 1 | 0.6 | 0 | 1.1 |
| (7) Diffuse transmucosal inflammation | 7 | 0.5 | 12 | 1.8 |
| (8) Granulomas (mucin) | 0 | 2.0 | 0 | 0.5 |
| (9) Granulomas (epithelioid) | 7 | 12.4 | 0 | 0.1 |
| Polymorph inflammation | ||||
| (10) Lamina propria polymorphs | 10 | 0.9 | 11 | 1.2 |
| (11) Focal crypt epithelial polymorphs | 9 | 1.1 | 6 | 1.0 |
| (12) General crypt epithelial polymorphs | 1 | 0.3 | 3 | 3.7 |
| (13) Crypt abscess | 7 | 0.6 | 10 | 1.8 |
| (14) Polymorph exudate | 1 | 0.6 | 4 | 1.6 |
| Epithelial changes | ||||
| (15) Erosion/ulceration | 4 | 1.2 | 3 | 0.7 |
| (16) Mucin depletion | 3 | 0.6 | 9 | 1.7 |
| (17) Paneth cells distal to hepatic flexure | 0 | 0.7 | 0 | 1.8 |
| Epithelial associated changes | ||||
| (18) Increased intraepithelial lymphocytes | 0 | 2.5 | 0 | 0.4 |
| (19) Increased subepithelial collagen | 0 | 1.0 | 0 | 1.0 |