Standard histomorphometric variables used in multiple regression analysis
| Variable type | Variable | Definition (units) |
|---|---|---|
| The variables were defined and measured according to the guidelines detailed in Parfitt et al.18 Histomorphometric parameters numbered in column 2 for reference to figs 5 and 6. | ||
| Static trabecular bone parameters | Cancellous bone volume (1) | BV/TVt (%) |
| Wall thickness (2) | (μm) | |
| Osteoid surface (3) | OS/B (%) | |
| Osteoid volume (4) | OV/BV (%) | |
| Osteoid thickness (5) | (μm) | |
| Osteoblast surface (6) | ObS/BS (%) | |
| Eroded surface (10) | ES/BS (%) | |
| Osteoclast surface (11) | OcS/BS (%) | |
| Osteoclast number (12) | Noc/TVt (/mm2 ×10−2) | |
| Cancellous thickness (13) | (μm) | |
| Cancellous number (14) | (/mm3) | |
| Cancellous separation (15) | (μm) | |
| Static cortical bone parameters | Cortical thickness (16) | (μm) |
| Cortical volume (17) | CV/TVc (%) | |
| Cortical wall thickness (18) | (μm) | |
| Osteoclast number (19) | Noc/TVc (/mm2 ×10−2) | |
| Subcortical osteoclasts (20) | Noc/BSs (/mm ×10−2) | |
| Dynamic parameters | Cancellous apposition rate | (μm/day) |
| Mineralising surface 1 (7) | MS/BS or dLS+1/2sLS (%) | |
| Mineralising surface 2 (8) | MS/OS or sLS+dLS (%) | |
| Mineralising surface (9) | dLS/sLS (%) | |
| Cortical apposition rate (21) | (u+C4m/day) | |
| Bone formation rate (22) | BFR/BVt [dLS+1/2sLS] (%/year) | |