Table 2

Demographic details of patients, risk factors for their OSCCs, and TP53 gene and p53 protein alterations

Sequence of exons 5–8 of the TP53 gene
TnSex/ageSmoking habits (cig/day)Alcohol habits (U/day)p53 IHCMutationExonCodonAA change
*Compatible with well described p53 polymorphism.
AA, amino acid; cig, cigarettes; IHC, immunohistochemistry; NS, non-smoker; OSCC, oral squamous cell carcinoma; unk, unknown; U, units of alcoholic beverage.
T1M/81NS<2NegativeCGA>TGA6213Arg→Stop
T4F/55>20>4NegativeNo
T12F/79NS<2NegativeNo
T17M/68<10>4NegativeDeletion 2bp5145Frameshift
T19M/6710–202–4NegativeCGA>TGA6213Arg→Stop
T27F/63>20>4<25%CGA>CGG*6*213*Arg→Arg*
T31F/81NS<2<25%No
T38F/56unkunk25–50%CGC>CAC5175Arg→His
T46M/45unkunk>75%CAT>CGT6193His→Arg
T52M/39>202–4>75%TTT>CTT5134Phe→Leu