Table 1

The Freiburg cases of chronic neutrophilic leukaemia, arranged in chronological order

Patient	Sex	Age (years)	BCR/ABL-status	WBC (×10⁹/l)	% N	Hb (g/l)	Plt. ×10³	F-Up (months)	SpM	NAP	Outcome
In patients 2–8, 10, 11 and 13 the outcome was fatal. Haematological data are those found at the time of diagnosis. *, indicates that the patient is alive and the number indicates the number of months since diagnosis; †, indicates that the patient is dead and the number indicates the number of months after diagnosis.
BMT, bone marrow transplantation; CR, complete remission; F-Up, follow up period; Hb, haemoglobin; IF-α, interferon α; %N, % of neutrophils; NAP, neutrophil alkaline phosphatase score (normal range, 20–120); NI, not investigated; Plt., platelet count; SpM, splenomegaly; WBC, leucocyte count; (+), mild form.
1	F	40	Negative	22.6	84	129	106	73*	+	298	BMT, CR
2	M	69	Negative	34.4	68	117	105	14†	(+)	NI	Chloroma
3	M	69	Negative	11.3	72	79	117	9†	(+)	NI	Pneumonia
4	M	69	Negative	49.2	88	90	84	19†	+	2	Cerebral haemorrhage
5	F	77	Negative	89.0	95	102	135	15†	(+)	91	Chloroma
6	M	64	Negative	41.7	84	109	281	9†	+	55	Cerebral haemorrhage
7	F	77	Negative	93.0	74	77	116	8†	+	293	Cerebral haemorrhage
8	F	81	Negative	35.0	95	108	189	38†	+	270	Cerebral haemorrhage
9	F	37	Negative	36.2	92	143	273	41*	+	383	IFN-α
10	F	72	Negative	38.0	90	89	47	23†	(+)	low	Blast crisis
11	M	64	Negative	109.0	87	113	161	10†	+	364	Cerebral haemorrhage
12	F	52	Negative	30.0	82	140	182	16*	(+)	310	No treatment
13	M	72	Negative	22.8	88	93	62	2†	+	40	Cerebral haemorrhage
14	F	63	Negative	24.6	78	123	210	5*	(+)	46	No treatment