Immunohistochemical analysis of BMP expression in 47 osteosarcomas
| Antibody | ++ | + | − | Total BMP positive (%) |
|---|---|---|---|---|
| Immunostaining results are graded as follows: ++, 50–95% of tumour cells positive; +, 10–49% of tumour cells positive; −, less than 10% of tumour cells positive or no visible staining. | ||||
| BMP, bone morphogenetic protein. | ||||
| BMP-2/4 | 4 | 24 | 19 | 28 (59) |
| BMP-3 | 4 | 20 | 23 | 24 (51) |
| BMP-5 | 19 | 22 | 6 | 41 (87) |
| BMP-6 | 13 | 18 | 16 | 31 (68) |
| BMP-7 | 27 | 16 | 4 | 43 (91) |
| BMP-8 | 15 | 27 | 5 | 42 (90) |