Table 2

Differential diagnosis between T cell rich, large B cell lymphoma (TCRBCL), lymphocyte predominant Hodgkin's lymphoma (LP-HL), and common Hodgkin's lymphoma (CHL)

Diagnostic criteriaTCRBCLLP-HL Nodular/diffuseCHL
EMA, epithelial membrane antigen; FDC, follicular dendritic cells; L/H, lymphocytic/histiocytic (popcorn); RS, Reed Sternberg.
*Weakly positive in some instances; †negative in rare instances; ‡usually overexpressed; §in 1–2% of the cases T cell receptor gene rearrangement.
Neoplastic component
Cell distributionDispersedWithin the nodulesDispersed
L&H/L&H-like cells−/++/−
RS/RS-like cells−/+−/+
CD45 expression++
CD30 expression−*−*+
CD15 expression+/−
CD79a expression+/−−/+−/+ Variable
CD20 expression+†+†−/+ Variable
BOB.1 expression++
Oct2 expression+‡+‡Rare
CD3 expression−/+
EMA expression+/−+/−Rare
J chain expression+/−+/−
MIB-1/Ki-67 expressionHighHighHigh
EBV+ Variable
Ig gene rearrangement++
Reactive component
T cellsNumerousModerateVariable
T cells with irregular nuclear profile+/−−/+
Bcl-6+/CD57+ rosettesNumerous
Amount of TIA-1+ cellsVery highLowHigh
Amount of CD20+ small lymphocytesLowHighLow
Clinical findings
Bone marrow involvement+/−
Orderly progression in the spread+