EWS fusion types described in Ewing’s sarcoma family of tumours (ESFT) and other sarcomas
| Translocation | Gene fusion | Tumour type (% of tumours with this EWS gene rearrangement) |
|---|---|---|
| The presence of EWS–ETS gene rearrangements is increasingly used to define ESFT. The involvement of the EWS gene on chromosome 22q is consistent; this can partner with several different ETS gene family members located on various chromosomes, but most frequently with FLI1 on chromosome 11 in ESFT. Rearrangements of the EWS gene on chromosome 22q12 with other chromosomes have also been described in other less common sarcoma types (shown in italics). | ||
| t(11;22)(q24;q12) | EWS–FLI1 | ESFT (85%) |
| t(21;22)(q22;q12) | EWS–ERG | ESFT (10%) |
| t(7;22)(p22;q12) | EWS–ETV1 | ESFT (rare) |
| t(17;22)(q12;q12) | EWS–E1AF | ESFT (rare) |
| t(2;22)(q33;q12) | EWS–FEV | ESFT (rare) |
| t(12;22)(q13;q12) | EWS–AFT1 | Clear cell sarcoma |
| t(11;22)(q13;q12) | EWS–WT1 | Desmoplastic small round cell tumour |
| t(9;22)(q22;q12) | EWS–CHN | Myxoid chondrosarcoma |
| t(12;22)(q13;q12) | EWS–CHOP | Myxoid liposarcoma |