Table 2

Frequency of APC mutation and budding in colorectal cancers stratified as MSI-H, HNPCC, MSI-L, and MSS

CategoryAPC mutationBudding
APC mutation (χ2 analysis): A v C, p=0.01; A v D, p=0.01.
Budding (χ2 analysis): A v C, p <0.001; A v D, p <0.001, B v D, p=0.04.
HNPCC, hereditary non-polyposis colorectal cancer; MSI-H, high degree of microsatellite instability; MSI-L, low degree of microsatellite instability; MSS, microsatellite stable.
A MSI-H (n=21)1 (4.8%)0 (0%)
B HNPCC (n=15)4 (26.7%)3 (20%)
C MSI-L (n=43)14 (32.6%)18 (41.9%)
D MSS (n=16)6 (37.5%)9 (56.2%)