Table 1

Detection of HPV DNA in sinonasal papillomas and carcinomas

			HPV type detected
Type of lesion	Technique	No. of cases	6	6/11	11	16	16/18	18	Other	Total (%) HPV+	First author (ref)	Year
SCP	IH	1								100	Syrjänen²⁹	1983
IP	ISH	14	1		5	5*				79	Syrjänen³⁷	1987
SCC	ISH	3				3				100
IP	SB	2			2					100	Respler⁴⁸	1987
IP	ISH	21			11					52	Weber⁴⁹	1988
IP	SB	2				1				50	Bradsma⁵⁰	1989
IP	ISH	7	3			1				57	Brandwein⁵¹	1989
SCP	SB	1							HPV57a	100	de Villiers⁵²	1989
VV	ISH	2							HPV2	100	Furuta⁵³	1989
IP	ISH	26†			3	1				16
IP	IH, ISH	21								62	Siivonen³²	1989
IP	PCR	ND								ND	Bryan⁵⁴	1990
IP	ISH	26†			3	1				16	Furuta⁵⁵	1990
SCC	ISH	40				4		1		12.5
IP	SB	7	1							14	Ishibashi⁵⁶	1990
IP	DB	1								4	Vonka⁵⁷	1990
IP	DB, ISH	26			3					12	Furuta⁵⁸	1991
SCC	DB, ISH	2				1				50
SCC	PCR	8	1							12	Judd⁵⁹	1991
IP	PCR	12								0
SCP	PCR	7			3					43
IP	ISH	9	8							89	Fu⁶⁰	1992
IP	ISH	15	6							40	McLachlin⁶¹	1992
SCP	PCR	5	3							60
IP	PCR	29	2		5					24	Kashima⁶²	1992
SCP	PCR	26	3		1					15
SCC	PCR	24					1			4
SCC	PCR	49				6		1		14	Furuta⁶³	1992
IP	DB, SB	3								0	Ogura⁶⁴	1992
SCP	DB, SB	2			1					50
SCC, SCP	ISH, PCR	35	1							3	Sarkar⁶⁵	1992
IP	ISH, PCR	14		3						21.4	Buchwald⁶⁶	1993
IP	SB, PCR	8							1, ND	12.5	Gilain⁶⁷	1993
SCC	PCR	3				1				33	Tyan⁶⁸	1993
SCC, SCP	ISH, PCR	22						57b‡		86	Wu⁶⁹	1993
IP, SCC	PCR	29		14		19§				69	Arndt⁷⁰	1994
NP	PCR	30								0	Becker⁷¹	1994
IP	SB	17	1		1		3			29	Nakano⁷²	1994
IP	ISH	26								0	Tang⁷³	1994
SCP	ISH	7		6						86
IP	PCR	32							ND	63	Beck⁷⁴	1995
IP	PCR	32	12		6	1	1			63	Beck⁷⁵	1995
SCC	PCR	7				3	1			57
IP	ISH, PCR	52		3						6	Buchwald⁴²	1995
SCP	ISH, PCR	16		11						69	Buchwald⁷⁶	1995
CCP	ISH, PCR	5								0
SCC	ISH, PCR	5		1			1			40
IP	PCR	14								0	Hosone⁷⁷	1995
IP	PCR	20							9, ND	45	MacDonald⁷⁸	1995
IP	SB	1							57	100	Ogura⁷⁹	1995
IP, SCP	ISH, PCR	28	3		3	1				25	Gaffey⁸⁰	1996
IP, SCP	SB, PCR	12							5, ND	42	Ogura⁸¹	1996
IP	PCR	40	5	7	5					42.5	Shen⁸²	1996
SCC	PCR	14			3					21
IP	PCR	21		6				1		33	Bernauer⁸³	1997
SCP, IP	PCR, ISH	2¶		1				1		100	Buchwald⁸⁴	1997
SCC	PCR	9				3				33	Caruana⁸⁵	1997
IP	PCR	15	1		1	4				40
IP	PCR	38			30	18		2		79	Zhou⁸⁶	1997
IP	PCR	1	1							100	Harris⁸⁷	1998
IP	PCR	1**					1			100	Jones⁸⁸	1998
SCC	PCR	19				3				16	Mineta⁸⁹	1998
IP	PCR	30							ND	20	Mirza⁹⁰	1998
SCP	P	13							ND	ND	Franzman⁹¹	1998
IP		12							ND	ND
SCC		5							ND	ND
IP	PCR	36	1	2						9	Hwang⁹²	1998
IP+SCC	PCR	6				2				33
IP	PCR	10				4				40	Kassim⁹³	1998
IP	PCR	36							ND	58	Wang⁹⁴	1998
IP+SCC	PCR	16							ND	69
VC	PCR	13								0	Orvidas⁹⁵	1999
SCP	PCR	27					2			7.4	Saegusa⁹⁶	1999
IP	PCR	28					6			36
SCC	PCR	32					9			28
IP	ISH	1		1						100	Luceno⁹⁷	1999
SCP	ISH, PCR	5			2					40	Kraft⁹⁸	2000

			HPV type detected
Type of lesion	Technique	No. of cases	6	6/11	11	16	16/18	18	Other	HPV+	Total (%) First author (ref)	Year
Double infection with HPV-11 and HPV-16 in 3 cases; †same cases in Furata and colleagues^53,⁵⁵; ‡19 cases HPV-57b positive; §double infection with HPV-6/11 and HPV-16 in 13 cases; ¶both underwent malignant transformation; *extended to eustachian tube.
CCP, cylindric cell papilloma; DB, dot blot hybridisation; IH, immunohistochemistry; IP, inverted papilloma; ISH, in situ hybridisation; ND, not clearly defined; NP, nasal polyp; PCR, polymerase chain reaction; SB, southern blot hybridisation; SCC, squamous cell carcinoma; SCP, squamous cell papilloma; VC, verrucous carcinoma; VV, verruca vulgaris of nasal vestibulum.
Type of lesion	Technique	No. of cases	HPV type detected							Total (%) HPV+	First author (ref)	Year
			6	6/11	11	16	16/18	18	Other
IP+SCC	ISH, PCR	34(4)	1		1					6		2001
CCP	ISH, PCR	4								0
IP	IH	57								9	Delank⁹⁹	2000
SCC	ISH, PCR	14		3			2			36	Suarez¹⁰⁰	2000
SCC	PCR	35							ND	20	Buchwald¹⁰¹	2001
IP	PCR	20							ND	80	Schwerer¹⁰²	2001
SCC	PCR	5								40