Table 2

 Studies assessing B cell clonality in Hashimoto’s thyroiditis

First authorTechniqueNo. of casesClonalityYear/Ref
*Initially diagnosed as Hashimoto’s thyroiditis but revised to malignant lymphoma in view of clonal population. However, the histology of low grade mucosa associate lymphoid tissue lymphoma was noticed in these cases.
IHC, immunohistochemistry; PCR, polymerase chain reaction; SBH, Southern blot hybridisation; TGGE, temperature gradient gel electrophoresis.
KnowlesSBH1Yes (1/1)1989/7
HyjekIHC21Yes* (5/21)1988/10
MatsubayashiFlow cytometry and IHC5Yes (5/5)1990/12
WackerPCR (TGGE)18Yes (4/18)1994/24
TiemannPCR (TGGE)40Yes (8/40)1996/25
HsiPCR and IHC40No1998/14
Present studyPCR and sequencing10Yes (3/10)