Clinical characteristics of the patients studied
| UIP (n = 21) | NSIP (n = 6) | RB (n = 8) | |
|---|---|---|---|
| Values are mean (SEM). | |||
| *p = 0.002, UIP and NSIP greater than RB; †p = 0.002, UIP lower than normal; ‡p = 0.001, UIP lower than normal; §p = 0.002, UIP greater than RB; ¶p<0.0001, UIP greater than RB. | |||
| CT-alv, alveolar abnormality on high resolution computed tomography; CT-fib, fibrotic abnormality on high resolution computed tomography; DLCO, diffusing capacity for carbon monoxide; FF, fibroblastic foci profusion; FVC, forced vital capacity; NSIP, non-specific interstitial pneumonia; RBILD, respiratory bronchiolitic interstitial lung disease; TLC, total lung capacity; UIP, usual interstitial pneumonia. | |||
| Sex (M/F) | 14/7 | 4/2 | 2/6 |
| Age (years)* | 59 (7) | 61 (7) | 45 (11) |
| Duration of symptoms (years) | 2.1 (2.4) | 0.6 (0.5) | 4.4 (4.9) |
| Smoking (% current or ex-smokers) | 71 | 50 | 83 |
| FVC (% of that predicted)† | 61 (19) | 68 (21) | 72 (20) |
| TLC (% of that predicted)‡ | 66 (18) | 77 (23) | 85 (21) |
| DLCO (% of that predicted) | 44 (19) | 38 (17) | 58 (12) |
| CT-fib | 1.57 (0.68) | 1.53 (1.60) | 0.55 (0.07) |
| CT-alv | 1.44 (0.89) | 1.13 (1.71) | 1.55 (1.20) |
| Mean FF§ | 1.41 (0.82) | 0.58 (0.51) | 0.17 (0.41) |
| Maximum FF¶ | 1.59 (0.85) | 0.63 (0.48) | 0 (0) |