Clinical size greater than 1.0 mm12,13 |
Incomplete maturation12–16 |
Deep dermal mitoses13,14,15,16 |
Atypical mitoses12,13 |
Nuclear pleomorphism/hyperchromatism12,14 |
Focal sheet-like growth13,14 |
Ulceration (in absence of trauma)13 |
Abundant plasma cells in lesional inflammation15,16 |
Thickness (8 mm)13,15 |
Extension into subcutaneous tissue13,16 |
Pushing base16 |
Focal necrotic melanocytes16 |
Deep pigmentation10,16 |
Destruction of collagen12 |
Prominent pagetoid spread without epidermal hyperkeratosis12 |
Lymphatic spread/nodal involvement14,16,17 |