Table 1

Relative degree of vascular endothelial growth factor A mRNA expression determined by DNA microarray analysis (probe 210512_s_at) in different tissues and pathological states

TissueDiagnosisNMedianInterquartile rangeMann-Whitney U
p v normalp v metastatic
*Primary malignant disease with no evidence of distant metastasis; †These p values are not considered significant by the false discovery rate controlling procedure,54 with a desired false discovery rate <0.05.
AdiposeNormal37366259–591
Lipomas and lipomatosis7189116–9690.377
AdrenalNormal10499249–616
1° malignancy, no metastasis*10337242–5760.257
Benign tumours437459–7550.671
Blood vesselsNormal1111374–281
BoneNormal2157125–189
1° malignancy, no metastasis*25191121–6320.5170.767
Metastatic disease7225118–8200.380
Benign tumours58565–1220.190
Bone marrowNormal5185126–289
BreastNormal33166129–211
1° malignancy, no metastasis*276240160–3620.00010.197
Metastatic disease2118796–4120.495
Fibroadenomas9177159–2430.450
Cystosarcoma phyllodes33410.041†
Cell linesNormal998144–156
Untreated malignant11010862–2630.001
CervixNormal66217163–280
1° malignancy, no metastasis*20294182–4510.0110.699
Metastatic disease4322219–4370.105
Central nervous systemNormal16011178–157
1° malignancy, no metastasis*2111358–6070.6510.386
Meningiomas104827–1350.009
ColorectalNormal222150112–203
1° malignancy, no metastasis*158331238–466<0.00010.001
Metastatic disease34479291–725<0.0001
Benign tumours19255202–3580.0003
EndometriumNormal7452238–563
1° malignancy, no metastasis*96330212–5070.455
Metastatic disease12396246–4760.735
GallbladderNormal8607506–666
Head and neckNormal14140110–179
1° malignancy, no metastasis*30228145–3080.0020.326
Metastatic disease22316153–4210.003
Benign tumours21244140–3840.005
HeartNormal15345305–456
KidneyNormal76462382–532
1° malignancy, no metastasis*851461383–2435<0.00010.936
Metastatic disease61407166–29850.170
Oncocytomas8778492–10170.01
Other benign tumours4162111–230<0.0001
LiverNormal43533390–583
1° malignancy, no metastasis*18435315–6170.2820.130
Metastatic disease7341126–4780.020†
LungNormal100438354–567
1° malignancy, no metastasis*123390223–5910.1010.820
Metastatic disease5348107–8940.588
LymphoidNormal44230162–309
1° malignancy, no metastasis*785529–100<0.00010.024†
Metastatic disease322589–4320.828
Muscle (skeletal)Normal31389280–587
MyometriumNormal140718531–888
1° malignancy, no metastasis*21201779–16230.1560.079
Metastatic disease7246100–5610.009
Leiomyoma50485289–712<0.0001
Neuroendocrine1° malignancy, no metastasis*14236158–3740.166
Metastatic disease3373332–393
OesophagusNormal18271181–493
1° malignancy, no metastasis*17544388–8430.0060.923
OvaryNormal1179562–166
1° malignant disease94329202–523<0.00010.764
Metastatic disease61356185–532<0.0001
Benign tumours4813669–2010.089
PancreasNormal34446319–512
1° malignancy, no metastasis*52428320–5170.8180.768
Metastatic disease20430363–5100.962
Adenomas5428264–28120.669
PlacentaNormal46242–69
ProstateNormal34795469–1083
1° malignancy, no metastasis*65520267–8030.0040.665
Metastatic disease3668300–9220.404
Benign prostatic hypertrophy31464267–6180.003
Prostatic intraepithelial neoplasia41374749–15740.092
SkinNormal5512087–140
1° malignant disease38191108–331<0.00010.645
Metastatic disease2216687–3550.025†
Small intestineNormal129230181–301
1° malignancy, no metastasis*6196105–2810.2450.134
Inflammatory bowel disease49777–2510.041†
Adenomatous polyps6202145–2780.417
Soft tissue1° malignancy, no metastasis*58300156–5960.275
Metastatic disease15464216–764
Benign tumours3914991–242
StomachNormal23374284–465
1° malignancy, no metastasis*57288215–3660.0090.141
Metastatic disease13193112–3730.012
TestisNormal1517794–199
1° malignancy, no metastasis*185222–1610.0100.465
ThymusNormal652519–34
1° malignancy, no metastasis*32821–3410.395
ThyroidNormal111212567–1388
1° malignant disease26534293–9730.0030.242
Metastatic disease9464226–6010.001
Nodular hyperplasia15668592–9140.002
Benign tumours81448867–13880.206
UrinaryNormal7170115–421
1° malignancy, no metastasis*24531281–8680.0050.817
Metastatic disease3579131–20330.210
White blood cellsNormal79219–45
1° malignancy, no metastasis*6164117–2400.001