Table 2

Relative VEGF-A mRNA expression determined by quantitative in situ hybridisation in different tumour types

TissueTumour typeVEGF-A phosphorimage volume (relative units)U test
HIF-1α positiveHIF-1α negative
N*MedianIQRN*MedianIQR
*N, number of cores with number of cases in parentheses; †These p values are not considered significant by the false discovery rate controlling procedure,54 with a desired false discovery rate <0.05.
HIF-1α, hypoxia inducible factor 1α; IQR, interquartile range; VEGF-A, vascular endothelial growth factor A.
AdrenalCarcinoma3 (1)2683225861–275266 (2)4035021383–624290.4386
BreastDuctal adenocarcinoma9 (7)69823448–8322165 (78)64922759–106740.8651
EndometriumAdenocarcinoma06 (2)189425773–42790
KidneyAdenocarcinoma9 (3)194897169937–2635850
LiverHepatocellular carcinoma2 (1)3797822612–533446 (2)128478069–191910.0956
LungAdenocarcinoma71 (30)4021321246–6776744 (21)2462513594–536350.0394†
Neuroendocrine tumour015 (5)2656420574–41287
Squamous cell carcinoma35 (17)4131129085–7272841 (18)4008218356–760640.3842
OvaryAdenocarcinoma3 (1)1984217747–465963 (1)4099129618–423590.5127
Adenocarcinoma: endometrioid25 (14)2003914073–4003731 (15)1668610488–398390.4633
Adenocarcinoma: serous18 (10)12834338207–18521355 (22)2850219224–613540.0038
Adenocarcinoma: mucinous1 (1)525624 (12)42861785–68290.7815
Adenocarcinoma: clear cell6 (3)117882109480–13654127 (10)3573319849–1073390.0842
PancreasAdenocarcinoma6 (3)1828211131–338905 (2)3569323563–441150.1003
Soft tissueAngiosarcoma4 (2)1490743–1096920 (7)504269–22230.1879
Fibrosarcoma011 (4)23941275–5204
Gastrointestinal stromal tumour1 (1)1077916 (6)36781091–162900.4142
Leiomyosarcoma4 (2)129202420–3470914 (5)1209710030–443810.3956
Liposarcoma3 (1)1877212333–2469925 (9)915116–32240.0067
Malignant fibrous histiocytoma11 (5)91652893–1265732 (13)65273195–117390.6361
Rhabdomyoscarcoma7 (3)134597475–7352839 (15)27921423–56780.0011
Synovial sarcoma4 (2)139328009–3579029 (11)46003096–89180.1856
ThyroidCarcinoma38 (15)3007322677–4661072 (26)3702421798–572020.2659
Carcinoma: anaplastic3 (3)1337113196–331803 (4)90735359–275470.3092
Carcinoma: medullary9 (3)2994126268–14351126 (9)1778812459–453160.0326†
Carcinoma: poorly differentiated11 (4)1792515558–4524011 (4)4205426370–527690.1396
Adenocarcinoma: follicular9 (3)8390952089–987210