Table 1

Overview of different studies on the prognostic value of mitotic activity in invasive breast cancer

First author	Ref	P/R	N	Subgroup	Overall survival	Significance	Independent value
Not all these studies used independent patient groups.
LN, lymph node; NS, not significant; P, prospective, R, retrospective.
Aaltomaa	121	R	293	LN–	0.005	–	Yes
	121	R	224	LN+	0.004	–	Yes
	122	R	106	All	<0.001	<0.001	Yes
	119	R	281	LN–	0.0115	0.0007	Yes
	118	R	688	All	<0.0001	<0.0001	Yes
	120	R	611	All	<0.001	<0.001	Yes
Baak	104	R	271	Ductal	–	<0.001	Yes
	105	R	82	Ductal	–	0.0254	Yes
	159	P	576	LN–, <55	<0.0001	<0.0001	Yes
Barbareschi	124	R	178	LN–	0.03	–	No
Biesterfeld	125	R	104	All	–	<0.0001	Yes
	152	R	108	LN+	–	0.0093	Yes
Bos	107	R	153	All	0.046	0.017	Yes
Chen	155	R	255	LN–	NS	NS	No
Clahsen	82	R	441	LN–	<0.01	–	–
Clayton	127	R	378	LN–	–	<0.0001	Yes
	126	R	399	LN+	–	<0.0001	Yes
Collan	108	R	120	All	–	0.001	Yes
Colpaert	128	R	104	LN–	<0.0001	–	No
Jong	13	R	112	All	–	0.0009	Yes
Eskelinen	129	R	216	All	0.01	–	Yes
Groenendijk	4	R	387	All	<0.0001	–	–
Ikpatt	130	R	300	All	–	<0.0001	Yes
Jannink	112	R	186	All	–	<0.001	Yes
	113	R	189	All	–	<0.001	Yes
Joensuu	131	R	311	All	–	<0.0001	–
Kato	156	R	70	LN–	–	NS	No
	132	R	422	All	<0.0001	<0.0001	Yes
Keshgegian	133	R	126	All	0.0003	–	–
Kronqvist	135	R	364	All	<0.0001	–	Yes
	134	R	202	All	–	0.0001	Yes
Ladekarl	138	R	71	Ductal	–	0.1	Yes
	137	R	98	LN–	–	0.0005	Yes
Laroye	157	R	76	All	–	NS	Yes
Le Doussal	95	R	1262	Ductal	<0.0001	0.002	Yes
Linden	160	P	195	All	0.001	–	Yes
	114	R	156	All	0.001	0.005	Yes
Lipponen	139	R	111	All	0.001	0.001	Yes
	141	R	363	All	0.004	0.001	Yes
	140	R	202	All	0.012	–	Yes
Liu	142	R	791	All	<0.0001	<0.0001	Yes
Mandard	144	R	281	LN–, prem.	<0.001	<0.001	Yes
Manders	145	R	137	All	0.0070	0.0017	Yes
Page	146	R	311	LN–	NS	0.01	Yes
Pietilainen	78	R	191	All	–	0.0025	Yes
Russo	90	R	646	All	<0.0001	–	Yes
Simpson	147	R	560	LN+	0.004	–	Yes
Theissig	148	R	92	All	–	<0.0001	Yes
Thor	46	R	486	All	0.0056	–	Yes
Toikkanen	149	R	217	Lobular	–	0.0001	Yes
Tosi	150	R	350	All	0.025	–	Yes
Uyterlinde	115	R	63	Ductal	–	0.008	Yes
	116	R	225	Ductal	–	<0.0001	Yes
	117	R	295	Ductal	–	<0.0001	Yes
Van Diest	111	R	211	<55	–	<0.0001	Yes
	110	R	20	LN+	–	0.004	–
	9	R	148	All	–	0.0001	Yes
Younes	151	R	300	Ductal	–	0.0032	Yes