Table 1

 Loss of heterozygosity analysis of the 1p34.1 region in primary hepatocellular carcinomas

PatientAge/SexAetiologyTumour size (cm)GradingD1S421D1S2802D1S451D1S2677Mutation
*PCR products have also been sequenced.
Four microsatellite markers from the 1p34.1 region (D1S421, D1S2677, D1S451, and D1S2802), which are located centromeric and telomeric of the PRDX1 gene, were used.
HBV, hepatitis B virus; HCV, hepatitis C virus; LOH, loss of heterozygosity; ROH, retention of heterozygosity.
HCC176/MHCV, cirrhosis4.2G1NIROHROHNINone*
HCC767/MNo cirrhosis17G2NIROHNIROHNone*
HCC855/FHBV, cirrhosis5.5G2NIROHNIROHNone*
HCC951/FHBV, fibrosis2.4G3NIROHNIROHNone*
HCC1080/FHCV, cirrhosis4.2G2ROHROHROHROHNone*
HCC1162/MHaemochromatosis, fibrosis10.5G2ROHROHNININone
HCC1248/MHCV, cirrhosis2.5G3NIROHNIROHNone*
HCC1382/MNo cirrhosis7.0G2NININIROHNone*
HCC1469/FHBV, fibrosis8.5G2NIROHNIROHNone
HCC1571/MNo cirrhosis1.6G2NIROHNININone
HCC1681/FNo cirrhosis18.0G1ROHNINININone*
HCC1764/MHBV, cirrhosis2.1G2NININIROHNone
HCC1848/MHCV, cirrhosis13.0G2ROHROHNININone
HCC1956/MAlcohol, no cirrhosis2.1G1NIROHROHNINone
HCC2049/MHBV, cirrhosis10.0G2ROHROHROHROHNone
HCC2137/FNo cirrhosis5.0G2ROHROHNIROHNone
HCC2246/MHCV, cirrhosis6.0G2NININIROHNone
HCC2370/MHCV, cirrhosis2.2G1NIROHNIROHNone*
HCC2467/Mcirrhosis5.0G2NIROHNIROHNone*
HCC2565/FAlcohol, cirrhosis3.8G2NILOHNILOHNone*
HCC2736/MHBV, alcohol, cirrhosis8.0G3ROHROHNININone
HCC2863/MAlcohol, cirrhosis3.5G2NININININone
HCC2956/MAlcohol, no cirrhosis4.0G2NININININone*
HCC3065/FNo cirrhosis11.0G1LOHLOHNILOHNone*
HCC3151/MHCV, cirrhosis2.5G2NIROHNIROHNone*
HCC3341/FAlagille syndrome, cirrhosis6.5G3NINIROHROHNone*
HCC3475/MNo cirrhosis5.0G2NIROHROHNINone
HCC3523/FHBV, cirrhosis18.0G2NILOHLOHNINone*
HCC3657/MHBV, cirrhosis6.5G2ROHROHNIROHNone
HCC3761/FHCV, fibrosis4.2G2NIROHROHROHNone
HCC3858/ MHCV, cirrhosis2.9G2ROHROHNININone
HCC3972/MCirrhosis6.5G2ROHNINININone
HCC4056/MHaemochromatosis, fibrosis4.8G2ROHNINININone
HCC4154/MHCV, fibrosis4.0G2ROHROHROHNINone
HCC4269/MCirrhosis4.5G2ROHROHROHROHNone
HCC4358/MAlcohol, cirrhosis7.5G3NININIROHNone