Table 1

 Demographic and clinical features of two HIV negative patients with KSHV/HHV-8 associated solid lymphomas

FeatureCase 1Case 2
CHOP, cyclophosphamide, doxorubicin, vincristine, prednisone; CEOP, cyclophosphamide, epidoxorubicin, vincristine, prednisone; EBV, Epstein-Barr virus; HHV-8, human herpesvirus type 8; HIV, human immunodeficiency virus; KSHV, Kaposi sarcoma associated herpesvirus; LDH, lactate dehydrogenase; LN, lymph node; NHL, non-Hodgkin lymphoma.
HHV-8 related diseaseNegativeNegative
HHV-8 viraemia (cp/ml)2314302850
EBV viraemia (cp/ml)Negative1074
CD4 cell (count/μl)470501
Stage (Ann Arbor)IVBIIIA
B symptomsSevere weight lossAbsent
Site of involvementLN, Waldeyer’s ring, soft tissue, spleenLN, spleen
Bulky diseasePresentPresent
Major laboratory abnormalities
    Severe anaemia (⩽80 g/l)NegativeNegative
    Thrombocytopenia (⩽100×109/l)NegativeNegative
    Coomb’s testNegativeNegative
    Abnormal LDH serum concentration (⩾460 U/ml)PresentNegative
    Hypoalbuminaemia (⩽30 g/l)PresentNegative
Outcome (months)Dead (2)Alive (8)
Cause of deathNHL