Demographic and clinical features of two HIV negative patients with KSHV/HHV-8 associated solid lymphomas
| Feature | Case 1 | Case 2 |
|---|---|---|
| CHOP, cyclophosphamide, doxorubicin, vincristine, prednisone; CEOP, cyclophosphamide, epidoxorubicin, vincristine, prednisone; EBV, Epstein-Barr virus; HHV-8, human herpesvirus type 8; HIV, human immunodeficiency virus; KSHV, Kaposi sarcoma associated herpesvirus; LDH, lactate dehydrogenase; LN, lymph node; NHL, non-Hodgkin lymphoma. | ||
| Age/Sex | 75/M | 52/M |
| HHV-8 related disease | Negative | Negative |
| HHV-8 viraemia (cp/ml) | 231430 | 2850 |
| EBV viraemia (cp/ml) | Negative | 1074 |
| CD4 cell (count/μl) | 470 | 501 |
| PS (ECOG) | 3 | 1 |
| Stage (Ann Arbor) | IVB | IIIA |
| B symptoms | Severe weight loss | Absent |
| Site of involvement | LN, Waldeyer’s ring, soft tissue, spleen | LN, spleen |
| Bulky disease | Present | Present |
| Major laboratory abnormalities | ||
| Severe anaemia (⩽80 g/l) | Negative | Negative |
| Thrombocytopenia (⩽100×109/l) | Negative | Negative |
| Coomb’s test | Negative | Negative |
| Abnormal LDH serum concentration (⩾460 U/ml) | Present | Negative |
| Hypoalbuminaemia (⩽30 g/l) | Present | Negative |
| Treatment | CHOP | CEOP |
| Outcome (months) | Dead (2) | Alive (8) |
| Cause of death | NHL | – |