Table 2

 Virological and immunophenotypic characteristics of KSHV/HHV-8 associated solid lymphomas

Case 1Case 2
+, almost all neoplastic cells positive; +/−, most neoplastic cells positive; −/+, minority of neoplastic cells positive; −*, few neoplastic cells positive; −, all neoplastic cells negative; NE, not evaluable.
AQP3, aquaporin 3; CIgG, cytoplasmic IgG; CLA, common leucocyte antigen; EBER, Epstein-Barr virus encoded small non-coding RNA; EBNA-1, Epstein-Barr virus nuclear antigen 1; EMA, epithelial membrane antigen; HHV-8, human herpesvirus type 8; IHC, immunohistochemistry; ISH, in situ hybridisation; KSHV, Kaposi sarcoma associated herpesvirus; ORF, open reading fragment; PCR, polymerase chain reaction; SELPLG, selectin P ligand; syn-1, syndecan 1; VEGF, vascular endothelial growth factor.
KSHV (IHC)ORF73+ORF73+
vIL-6−vIL-6+
KSHV (PCR)KS330+KS330+
ORF72+ORF72+
ORF9-3+ORF9-3−
EBER (ISH)+
EBNA-1 (PCR)+
LMP1 (IHC)
CLA/CD45−/+
EMA+−*
MUM1/IRF4++
CD138/syn-1+−/+
VS38c−/++
CD30−/+
ALK (ALK1)
CD20
CD40
CD79a
CD3−/+
CD5
CD43−/+−/+
CD45RO
CD10
Ki-67/MIB1++
κ/λ chain
CIgG++
CD15
CD68
S100
Keratin (AE1/AE3)
Keratin (MNF116)
Granzyme A−/+−*
AQP3−*+
SELPLG++
VEGF++