Table 1

 List of genes altered in giant hairy naevus (GHN) compared with normal skin from patients with GHN

Accession numberGeneSignificant fold change*Function
*p<0.05 for GHN versus normal skin from a patient with GHN.
AJ000503Dopachrome tautomerase (Δ isomerase, TRP-2)8.86Melanoma marker
D00632Glutathione peroxidase 3 (plasma)6.76Enzyme
X00734Tubulin, β54.74Structural protein
D50840UDP-glucose ceramide glucosyltransferase3.93Enzyme
U87947Epithelial membrane protein 33.63Membrane protein
L26232Phospholipid transfer protein3.59Transport protein
L05424Cell surface glycoprotein CD44 gene3.29Immune response
X82153Cathepsin K (pycnodysostosis)3.23Lysosomal enzyme
AF098641CD44 isoform RC (CD44) mRNA3.23Immune response
AJ001183SRY (sex determining region Y), box 103.15Differentiation
AL021396Hypothetical protein3.01Pathophysiology
J04430Acid phosphatase 5, tartrate resistant (TRAP)2.88Metabolism and transport
M77348Silver (Pmel 17, melanocyte specific gene)2.88Pigmentation gene
M59040CD44 antigen2.72Immune response
U60060Fasciculation and elongation protein, ζ1 (zygin I)2.61Cell signalling
AB011088Sperm associated antigen 92.57Development
D17547Dopachrome tautomerase (Δ isomerase, TRP-2)2.56Melanoma marker
J03553Human pulmonary surfactant protein (SP5) mRNA2.40Surfactant protein
AF035119Deleted in liver cancer 1 (DLC1)2.32Tumour suppressor gene
AF072468Jerky (mouse) homologue (JH8)2.08Epilepsy gene
AF044253K+ voltage gated channel, β member 2 (HKvβ2.2)2.08Signal transduction
X51420Tyrosinase related protein 1 (TRP-1)2.07Melanoma marker
D45288Expressed sequence tag1.97Unknown
X05276Tropomyosin 4−1.66Structural protein
D31716Basic transcription element binding protein 1−1.75Transcription
AW007731Purine rich element binding protein B−1.78DNA binding
U22431Hypoxia inducible factor 1, α subunit−1.84Stress response
X15804Actinin, α1−1.88Structural protein
D87434KIAA0247 gene product−1.89Unknown
S81439Early growth response α−1.90Cell cycle regulation
AB023209Palladin−1.90Protein folding
AL049288Bladder cancer associated protein−1.90Protein marker
M28170CD19 antigen−1.92B cell signalling
AJ224901Zinc finger protein 198−1.98Cell signalling
U84011Amylo-1,6-glucosidase, 4-α-glucanotransferase enzyme−1.98Glycogen debranching
U84487SOCS-1 (fractalkine, neurotactin)−1.99Cell signalling
U94905Diacylglycerol kinase, ζ (104 kDa) (DAG)−2.01Cell signalling
AB014511ATPase, class II, type 9A−2.04Metabolism
AF041080Hect domain and RLD 2−2.11Unknown
AI222594Expressed sequence tag−2.11Unknown
X16663Haemopoietic cell specific Lyn substrate 1−2.12B cell signalling
D13629Kinectin 1 (kinesin receptor)−2.12Motor cargo proteins
AB005754Lymphokine activated killer (LAK-1)−2.12Immune response
U85193Nuclear factor I/B−2.16Stress response
L77886Protein tyrosine phosphatase, receptor type, K−2.18Signal transduction
AL096780Choline kinase like−2.19Metabolism
U82328Pyruvate dehydrogenase complex−2.20Metabolism
D13639Cyclin D2−2.23Cell cycle
M63193Platelet derived endothelial cell growth factor 1(PD-EGF)−2.23Angiogenesis
AL021154E2F transcription factor 2−2.27Cell cycle
AL050378Expressed sequence tag−2.28Unknown
J00153α Globin gene cluster on chromosome 16−2.29Metabolism
D29805UDP-β-1,4-galactosyltransferase, polypeptide 1−2.30Growth and development
X77777Vasoactive intestinal peptide receptor 1−2.30Growth and differentiation
AL049946DKFZP564I1922 protein−2.31Unknown
AB022660KIAA0437 protein−2.32Unknown
X02160Insulin receptor−2.32Cell signalling
D61391Phosphoribosyl pyrophosphate synthetase protein 1−2.33Metabolism
AB002298KIAA0300 protein−2.37Unknown
AB029018KIAA1095 protein−2.39Unknown
AI651806Cysteine rich motor neurone 1−2.43Cell signalling
M64572Protein tyrosine phosphatase, non-receptor type 3−2.45Signal transduction
AF052142Expressed sequence tag−2.50Unknown
D64110BTG family, member 3−2.50Cell growth and regulation
X05409Aldehyde dehydrogenase 2, mitochondrial−2.50Metabolism
X62534HMG protein 2 (HMGB2)−2.52DNA integration
AF056087Secreted frizzled related protein 1 (hsFRP)−2.67Tumour suppressor
AF063002Four and a half LIM domains 1 (FHL-1)−2.72Myogenesis
AF099989Ste-20 related kinase−2.75Growth and differentiation
U90907Expressed sequence tag−2.76Unknown
M25079Haemoglobin β−2.76Metabolism
X99268Twist (drosophila) homologue−2.81Transcription factor
M27492Interleukin 1 receptor, type I−2.85Inflammatory response
U13616Ankyrin 3, node of Ranvier (ankyrin G)−2.87Cell signalling
L13463Regulator of G protein signalling 2, 24 kDa−2.95Signal transduction
AI687419Expressed sequence tag−2.96Unknown
X59766α-2 Glycoprotein 1, zinc−3.01Acute phase response
AF099935Tumour necrosis factor induced protein−3.18Immune response
M26326Keratin 18−3.20Structural protein
M31682Inhibin, β-B (activin AB β polypeptide)−3.26Cell signalling
U10550GTP binding protein−3.26Cell signalling
U97519Podocalyxin like−3.78Cell surface marker
U67156Mitogen activated protein kinase kinase kinase 5−3.78Signal transduction
L06797Chemokine (C-X-C motif), receptor 4 (fusin)−3.84Inflammatory response
AI445461Transmembrane 4 superfamily member 1−3.97Membrane transport
U43626γ-Aminobutyric acid (GABA) A receptor, ϵ−4.90Neurotransmitter
AJ238246Keratin 7−4.91Structural protein
L11706Lipase, hormone sensitive−5.20Metabolism
D78611Mesoderm specific transcript (mouse) homologue−5.22Growth and differentiation
AF022375Vascular endothelial growth factor (VEGF)−5.70Angiogenesis
D45371Adipose most abundant gene transcript 1−7.58Metabolism
U76456Tissue inhibitor of metalloproteinase 4−8.60Extracellular matrix
AA128249Fatty acid binding protein 4, adipocyte−8.75Metabolism
X03350Alcohol dehydrogenase 2 (class I), β polypeptide−9.55Metabolism
M12963Alcohol dehydrogenase 1 (class I), α polypeptide−12.05Metabolism