Table 2

 List of genes altered in normal skin of individuals with giant hairy naevus (GHN) versus skin from normal controls

Accession numberGeneSignificant fold change*Function
*p<0.05 for normal skin with hairy naevus versus normal control skin
M84526D component of complement (adipsin)21.8Immune response
X52022Collagen, type VI, α314.2Structural protein
M15856Lipoprotein lipase13.9Metabolism
X07979Integrin β1 subunit10.1Extracellular matrix
J03040Osteonectin9.3Cell adhesion
L25286Collagen, type XV, α18.7Structural protein
XM_056455Melanoma associated gene8.5Melanoma marker
X05610Collagen, type IV, α28.5Structural protein
U20982Insulin-like growth factor binding protein 4 (IGFBP4)8.4Growth and differentiation
D10040Fatty acid coenzyme A ligase, long chain 28.0Metabolism
L19182Insulin-like growth factor binding protein 7 (IGFBP7)8.0Growth and differentiation
M62403Insulin-like growth factor binding protein 4 (IGFBP4)7.9Growth and differentiation
X05409Aldehyde dehydrogenase 2 family (mitochondrial)7.8Metabolism
M33210Human colony stimulating factor 1 receptor (CSF1R)7.8Immune response
X86693SPARC-like 1 (mast 9, hevin)7.7Tissue remodelling
AL039458Orthologue of mouse integral membrane glycoprotein LIG-16.9Membrane glycoprotein
L11706Lipase, hormone sensitive6.8Metabolism
M81945Human CD34 gene, promoter and coding sequence6.6Immune response
L42373Protein phosphatase 2, α isoform6.5Signal transduction
AL050159DKFZP586A0522 protein6.4Unknown
AL049798Dermatopontin6.3Extracellular matrix
X13839Actin, α2, smooth muscle, aorta6.0Structural protein
J03278Platelet derived growth factor receptor, β polypeptide5.7Cell growth
AI813532Tumour necrosis factor receptor superfamily, member 1B5.4Immune response
U65093Cbp/p300 interacting transactivator, 24.6Proliferation and cell cycle
M95787Transgelin4.6Gap junction protein
W27949Chromosome 6 open reading frame 34 (BACH1)4.2Tumour suppressor gene
AF007150Angiopoietin-like 24.1Lipid metabolism
U67963Lysophospholipase like3.2Lipid metabolism
U05861Hepatic dihydrodiol dehydrogenase gene3.1Metabolism
D16294Acetyl coenzyme A acyltransferase 2 (mitochondrial)3.0Metabolism
X02160Insulin receptor2.9Cell signalling
X96752L-3-hydroxyacyl coenzyme A dehydrogenase, short chain2.6Metabolism
U29091Selenium binding protein 12.6Peroxisome proliferation
L27560Insulin-like growth factor binding protein 5 (IGFBP5)2.6Growth and differentiation
U72649BTG family, member 22.4Cell growth and regulation
AA181053Parvin, β−3.9Cell matrix and adhesion
U72511B cell associated protein−4.3Immune response
AA524547FXYD domain containing ion transport regulator 1−6.1Membrane transport
N36638Protein phosphatase 1, regulatory (inhibitor) subunit 3C−7.0Signal transduction
X00351Actin, β−23.7Structural protein