Table 1

 Association of HIF-1α expression with clinicopathological features in patients with invasive breast cancer (n = 200)

nHIF-1α <1%HIF-1α >1%p Value (χ2)
*Lobular breast carcinomas showed significantly less frequent HIF-1α expression than ductal cancers (p = 0.03).
CA IX, carbonic anhydrase IX; GLUT-1, glucose transporter 1; HIF-1α, hypoxia inducible factor 1α; NA, not associated.
Total20011288
Histological type
    Ductal1447668
    Lobular30228
    Tubular1192
    Papillary211
    Mucinous413
    Medullary404
    Apocrine202
    Cribriform330NA*
Histological grade
    I614615
    II784830
    III611843<0.001
Tumour size
    0–2 cm976136
    2–5 cm894247
    >5 cm14950.080
Lymph node status
    Negative1156946
    Positive7235370.127
Necrosis
    Negative16210161
    Positive381127<0.001
CA IX
    Negative17510867
    Positive25421<0.001
GLUT-1
    Negative1439746
    Positive571542<0.001