Table 4

 Comparison between T cell subsets and cytokine production in BALF and blood in patients with systemic sclerosis

BloodBALFp Value
Values are mean (SD).
CD8+ T cell counts, TNFα, and IL-1β were significantly higher in patients’ BALF than in blood (p<0.01, p<0.001, and p<0.01, respectively). Moreover, CD4+ T cell counts the CD4/CD8 ratio in BALF were significantly lower than in blood (p<0.05 and p<0.01, respectively). BALF, bronchoalveolar lavage fluid; IL-1β, interleukin 1β; TNFα, tumour necrosis factor α.
CD4+ cell count63.0 (3.3)51.1 (4.9)<0.05
CD8+ cell count22.7 (3.4)35.7 (2.6)<0.01
CD4/CD8 ratio2.8 (0.2)1.4 (0.1)<0.01
TNFα (pg/ml)38.6 (7.6)136.8 (50.7)<0.001
IL-1β (pg/ml)21.6 (9.4)49.5 (11.9)<0.01