Table 1

 Correlation between CRBP1 expression and histopathological parameters and methylation status in prostate adenocarcinoma and HGPIN lesions

CRBP1 immunoexpression
IncreasedNormalAbsentp Value
*In one HGPIN lesion the methylation status could not be assessed; †the p value was calculated by grouping together the cases with normal and increased CRBP1 expression.
HGPIN, high grade prostatic intraepithelial neoplasia.
Prostate adenocarcinoma (n = 36)
    Gleason score0.68
        4–610 (27.8%)4 (11.1%)12 (33.3%)
        7–105 (13.9%)2 (5.6%)3 (8.3%)
    Pathological stage0.89
        pT2a and pT2b8 (22.2%)3 (8.3%)9 (25.0%)
        pT3a and pT3b7 (19.4%)3 (8.3%)6 (16.7%)
    Methylation status0.54
        CRBP1 methylated6 (16.7%)4 (11.1%)7 (19.4%)
        CRBP1 unmethylated9 (25.0%)2 (5.6%)8 (22.2%)
HGPIN lesions (n = 35)*0.60†
    CRBP1 methylated0 (0%)2 (5.7%)1 (2.9%)
    CRBP1 unmethylated9 (25.7%)6 (17.2%)17 (48.5%)