Table 2

 Polymorphisms associated with increased prostate cancer risk

GeneChromosomal locusFunction
AR, androgen receptor.
TLR49qEncodes a receptor that is a central player in the signalling pathways of the innate immune response to infection by Gram negative bacteria
CDKN1B (p27)12pBelongs to the Cip/Kip family and functions as an important cell cycle gatekeeper
ARXqMay cause activation of androgen dependent genes
CYP1710qEnzyme responsible for the biosynthesis of testosterone.
SRD5A22pConverts testosterone to the more potent dihydrotestosterone