Expression of EGFR (Her-1), Her-2, Her-3, Her-4, and steroid receptors in metaplastic carcinomas
| Case/Histology | Antigens (% of positive tumour cells/staining intensity) | |||||||
|---|---|---|---|---|---|---|---|---|
| EGFR | Her-2 | Her-3 | Her-4 | AR | ER | PR | ||
| apo, apocrine features; AR, androgen receptor; casa, carcinosarcoma—epithelial staining; casa, carcinosarcoma—stromal staining; EGFR, epithelial growth factor receptor; ep, epithelioid; ER, oestrogen receptor; fasc, fascicular; GC, giant cells; het, heterologous elements; IDC, invasive ductal carcinoma; mat, matrix producing; PR, progesterone receptor. | ||||||||
| 1 Spindle/het | 20 | 2+ | 50/1+ | – | – | – | – | – |
| 2 Spindle/ep/het | 70 | 3+ | – | – | – | – | – | – |
| 3 Spindle/ep/het/GC | 40 | 2+ | – | – | – | – | – | – |
| 4 Spindle/het/GC | – | – | – | – | – | 90/2+ | – | – |
| 5 Spindle/het/GC | 20 | 1+ | – | – | – | – | – | – |
| 6 Spindle/het/GC | 30 | 2+ | – | – | – | – | – | – |
| 7 Spindle/mat | 10 | 2+ | – | – | – | – | – | – |
| 8 Spindle/het/GC | – | – | – | 40/1+ | 40/2+ | – | – | – |
| 9 Spindle/het/apo | 70 | 3+ | – | – | – | – | – | – |
| 10 Spindle/fasc | – | – | – | – | – | – | – | – |
| 11 Spindle/ep/GC | – | – | – | – | – | – | – | – |
| 12 Spindle/fasc | 90 | 3+ | – | – | – | – | – | – |
| 13 Spindle/fasc | 90 | 3+ | – | – | – | – | – | – |
| 14 Spindle/fasc | 100 | 3+ | – | – | – | – | – | – |
| 15 Spindle/fasc | 80 | 3+ | – | – | – | – | – | – |
| 16 Spindle/fasc | 20 | 1+ | – | – | – | – | – | – |
| 17 Casa/IDC | – | – | 30/2+ | – | – | 70/2+ | 70/3+ | 70/3+ |
| 17 Casa/spindle/GC | – | – | – | – | – | – | – | – |
| 18 Casa/IDC | 20 | 2+ | – | – | – | – | – | – |
| 18 Casa/spindle | 50 | 3+ | – | – | – | – | – | – |
| 19 Casa/IDC | – | – | – | – | – | – | – | – |
| 19 Casa/spindle/fasc | – | – | – | – | – | – | – | – |
| 20 Casa/IDC | – | – | 20/1+ | 20/1+ | 20/1+ | – | 30/3+ | 30/3+ |
| 20 Casa/spindle/fasc | 60 | 3+ | – | – | – | – | – | – |