Table 1

 Reported bone marrow and lymph node granulomatous reactions in lymphomas

First authorLocationHistologyBone marrow and lymph node granulomatous reactions in lymphomas
HL%NHL (according to different classification systems)%Total number of cases examined
BM, bone marrow; CLL, small lymphocytic lymphoma/chronic lymphocytic leukaemia; HL, Hodgkin lymphoma; LN, lymph node; Mb, myeloblastoma; MM, multiple myeloma; NG, necrotising granulomas; NHL, non-Hodgkin lymphoma; SG, sarcoid granulomas.
Pease5,6BMSG83.6%7 NHL, not specified; 2 multiple myelomas4%221 HL and NHL
Kim7LNsSG1 nodular mixed histiocytic–lymphocytic lymphoma; 2 histiocytic lymphomas3.5%84 untreated NHL CLL, and Mb; Waldenström excluded
Sacks3BM, LNsSG172.8%608 HL
O’Carroll8BMSG65.6%107 HL
Yu9BMSG1 nodular poorly differentiated lymphoma; 2 diffuse poorly differentiated lymphomas; 4 diffuse histiocytic lymphomas; 1 diffuse mixed histiocytic–lymphocytic lymphoma; 1 unclassified splenic lymphoma9 cases observed
Choe10BMSG3 poorly differentiated lymphocytic lymphomas; 3 histiocytic lymphomas; 3 MMs; 1 acute lymphoplastic leukaemia2.6%372 NHL
Bhargava13BMSG70.1% of all biopsies8 NHL, not specified; 1 acute lymphoblastic leukaemia; 1 CLL 1 MM0.16% of all biopsies6988 bone marrow biopsies; 72 specimens with granulomas
Spier11LNsSG11 “Lennert” lymphomas of B and T cell origin3.1%355 NHL
Hollingsworth2BMClusters of histiocytes5 Burkitt lymphomas; 2 follicular lymphomas7 cases observed
Dunphy4LNsSG1 immunocytomaSingle case observed
Kornacker1BMSG1 diffuse large B cell lymphomaSingle case observed
Blanco14LNsNG3 CLL3 cases observed
Haralambieva12LNsSG4 Burkitt lymphomas6%67 Burkitt lymphomas