Table 4

 Possible mechanisms of disease in CFS based on three gene expression studies, each on patients with CFS and normal controls

MechanismPresent studyPowell and colleagues4Vernon and colleagues5
CSF, chronic fatigue syndrome; qPCR, quantitative polymerase chain reaction.
Microarray (9522 genes)/qPCR; 25 CFS; 25 normalDifferential display/qPCR; 7 CFS; 4 normalFilter array (1764 genes); 5 CFS; 17 normal
T cell activationCD2BP2, IL-10RAMoesin, CTSCITGA, NFATC3
Immune responsePRKCL1TNF, MAILIL-8, CMRF35, ICAM2, ITGB, IER2, PLA2G2A, LCP-1, PRKCL
NeuronePRKCL1, GSN, KHSRP, NTE, GABARAPL1HD, PRKCL, ataxin, ADRA2A, DCTN1
MitochondrionEIF4G1, EIF2B4, MRPL23SLC25A16, MCFP
Skeletal muscleGSNDCTN1
ThyroidGSNTHRAP2, SLC25A16GDC
Cell cycleANAPC11MAD1L1
ApoptosisPDCD2
TranscriptionPOLR2G, BRMS1RCOR3, POLR1B
PeroxisomeABCD4, PEX16