Table 1

 Correlation between HPV status and p16INK4A staining intensity

SampleHPV statusp16INK4A staining score
00a123
N refers to the number of cases tested. Not all cases included in our study were tested for HPV status. No case was found to be positive for HPV-31 or HPV-33.
Staining score: 0, no positive staining of dysplastic cells; 0a, basal layer staining; 1, basal layer staining plus <10% positive staining of dysplastic cells; 2, >10% but <50% positive staining of dysplastic cells; 3, >50% positive staining of dysplastic cells.
cGIN, cervical glandular intraepithelial neoplasia; hcGIN, high grade cervical glandular neoplasia; CIN, cervical intraepithelial neoplasia; HPV, human papillomavirus; SCC, squamous cell carcinoma.
Normal (n = 20)HPV−18/20 (90%)
HPV-6/112/20 (10%)
HPV-16
HPV-18
HPV unknown
% Total100%
CIN1 (n = 38)HPV−2/38 (5%)2/38 (5%)
HPV-6/113/38 (8%)1/38 (3%)
HPV-1621/38 (55%)
HPV-18
HPV unknown7/38 (19%)2/38 (5%)
% Total13%27%60%
CIN2 (n = 33)HPV−3/33 (9%)
HPV-6/112/33 (6%)
HPV-168/33 (24%)14/33 (43%)
HPV-181/33 (3%)
HPV unknown2/33 (6%)3/33 (9%)
% Total21%27%52%
CIN3 (n = 46)HPV +1/46 (2%)1/46 (2%)1/46 (2%)
HPV-6/111/46 (2%)
HPV-168/46 (18%)20/46 (44%)
HPV-182/46 (4%)2/46 (4%)
HPV unknown2/46 (4%)3/46 (7%)5/46 (11%)
% Total2%8%31%59%
SCC (n = 10)HPV−
HPV-6/11
HPV-169/10 (90%)
HPV-18
HPV unknown1/10 (10%)
% Total100%
cGIN (n = 7)HPV unknown1/17 (6%)6/17 (35%)
hcGIN (n = 10)HPV unknown1/17 (6%)9/17 (53%)
% Total12%88%
Adenocarcinoma (n = 10)HPV unknown10/10 (100%)
% Total100%