Correlation between HPV status and p16INK4A staining intensity
| Sample | HPV status | p16INK4A staining score | ||||
|---|---|---|---|---|---|---|
| 0 | 0a | 1 | 2 | 3 | ||
| N refers to the number of cases tested. Not all cases included in our study were tested for HPV status. No case was found to be positive for HPV-31 or HPV-33. | ||||||
| Staining score: 0, no positive staining of dysplastic cells; 0a, basal layer staining; 1, basal layer staining plus <10% positive staining of dysplastic cells; 2, >10% but <50% positive staining of dysplastic cells; 3, >50% positive staining of dysplastic cells. | ||||||
| cGIN, cervical glandular intraepithelial neoplasia; hcGIN, high grade cervical glandular neoplasia; CIN, cervical intraepithelial neoplasia; HPV, human papillomavirus; SCC, squamous cell carcinoma. | ||||||
| Normal (n = 20) | HPV− | 18/20 (90%) | ||||
| HPV-6/11 | 2/20 (10%) | |||||
| HPV-16 | ||||||
| HPV-18 | ||||||
| HPV unknown | ||||||
| % Total | 100% | |||||
| CIN1 (n = 38) | HPV− | 2/38 (5%) | 2/38 (5%) | |||
| HPV-6/11 | 3/38 (8%) | 1/38 (3%) | ||||
| HPV-16 | 21/38 (55%) | |||||
| HPV-18 | ||||||
| HPV unknown | 7/38 (19%) | 2/38 (5%) | ||||
| % Total | 13% | 27% | 60% | |||
| CIN2 (n = 33) | HPV− | 3/33 (9%) | ||||
| HPV-6/11 | 2/33 (6%) | |||||
| HPV-16 | 8/33 (24%) | 14/33 (43%) | ||||
| HPV-18 | 1/33 (3%) | |||||
| HPV unknown | 2/33 (6%) | 3/33 (9%) | ||||
| % Total | 21% | 27% | 52% | |||
| CIN3 (n = 46) | HPV + | 1/46 (2%) | 1/46 (2%) | 1/46 (2%) | ||
| HPV-6/11 | 1/46 (2%) | |||||
| HPV-16 | 8/46 (18%) | 20/46 (44%) | ||||
| HPV-18 | 2/46 (4%) | 2/46 (4%) | ||||
| HPV unknown | 2/46 (4%) | 3/46 (7%) | 5/46 (11%) | |||
| % Total | 2% | 8% | 31% | 59% | ||
| SCC (n = 10) | HPV− | |||||
| HPV-6/11 | ||||||
| HPV-16 | 9/10 (90%) | |||||
| HPV-18 | ||||||
| HPV unknown | 1/10 (10%) | |||||
| % Total | 100% | |||||
| cGIN (n = 7) | HPV unknown | 1/17 (6%) | 6/17 (35%) | |||
| hcGIN (n = 10) | HPV unknown | 1/17 (6%) | 9/17 (53%) | |||
| % Total | 12% | 88% | ||||
| Adenocarcinoma (n = 10) | HPV unknown | 10/10 (100%) | ||||
| % Total | 100% | |||||