Table 2

 Correlation between HPV status and MCM5 staining intensity

SampleHPV statusMCM5 staining score
00a123
N refers to the number of cases tested. Not all cases included in our study were tested for HPV status. No case was found to be positive for HPV-31 or HPV-33.
Staining score: 0, no positive staining of dysplastic cells; 0a, basal layer staining; 1, basal layer staining plus <10% positive staining of dysplastic cells; 2, >10% but <50% positive staining of dysplastic cells; 3, >50% positive staining of dysplastic cells.
cGIN, cervical glandular intraepithelial neoplasia; hcGIN, high grade cervical glandular neoplasia; CIN, cervical intraepithelial neoplasia; HPV, human papillomavirus; SCC, squamous cell carcinoma.
Normal (n = 20)HPV−18/20 (90%)
HPV-6/112/20 (10%)
HPV-16
HPV-18
HPV unknown
% Total100%
CIN1 (n = 31)HPV−1/31 (3%)1/31 (3%)1/31 (3%)1/31 (3%)
HPV-6/111/31 (3%)2/23 (6.5%)
HPV-165/31 (16%)6/31 (19%)5/31 (17%)
HPV-18
HPV unknown1/31 (3%)4/31 (13%)1/31 (3%)2/31 (6.5%)
% Total6%32%28%33%
CIN2 (n = 25)HPV1/25 (4%)1/25 (4%)1/25 (4%)
HPV-6/112/25 (8%))
HPV-161/25 (4%)8/25 (32%)5/25 (20%)3/25 (12%)
HPV-18
HPV unknown2/25 (8%)1/25 (4%)
% Total4%44%36%16%
CIN3 (n = 38)HPV−1/38 (3%)1/38 (3%)1/38 (3%)
HPV-6/111/38 (3%)
HPV-167/38 (17%)9/38 (24%)6/38 (15%)
HPV-181/38 (3%)1/38 (3%)
HPV unknown2/38(5%)5/38 (13%)1/38 (3%)2/38 (5%)
% Total8%36%33%23%
SCC (n = 8)HPV−
HPV-6/11
HPV-162/8 (25%)6/8 (75%)
HPV-18
HPV unknown
% Total25%75%
cGIN (n = 5)HPV unknown1/17 (6%)2/17 (12%)2/17(12%)
hcGIN (n = 12)HPV unknown2/17 (12%)2/17 (12%)8/17 (46%)
% Total18%12%24%46%
Adenocarcinoma (n = 10)HPV unknown1/10 (10%)4/10 (40%)5/10 (50%)
% Total10%40%50%