Table 3

 Correlation between HPV status and CDC6 staining intensity

SampleHPV statusCDC6 staining score
00a123
N refers to the number of cases tested. Not all cases included in our study were tested for HPV status. No case was found to be positive for HPV-31 or HPV-33.
Staining score: 0, no positive staining of dysplastic cells; 0a, basal layer staining; 1, basal layer staining plus <10% positive staining of dysplastic cells; 2, >10% but <50% positive staining of dysplastic cells; 3, >50% positive staining of dysplastic cells.
cGIN, cervical glandular intraepithelial neoplasia; hcGIN, high grade cervical glandular neoplasia; CIN, cervical intraepithelial neoplasia; HPV, human papillomavirus; SCC, squamous cell carcinoma.
Normal (n = 20)HPV−16/20 (80%)2/20 (10%)
HPV-6/112/20 (10%)
HPV-16
HPV-18
HPV unknown
% Total90%10%
CIN1 (n = 32)HPV−1/32 (3%)3/32 (9%)
HPV-6/112/32 (6%)2/32 (6%)
HPV-165/32 (16%)9/32 (28%)1/32 (3%)
HPV-18
HPV unknown4/32 (13%)4/32 (13%)1/32 (3%)
% Total38%56%6%
CIN2 (n = 27)HPV−2/27 (7%)1/27 (4%)
HPV-6/112/27 (7%)
HPV-167/27 (26%)8/27 (30%)3/27 (11%)
HPV-181/27 (4%)
HPV unknown1/27 (4%)2/27 (7%)
% Total37%52%11%
CIN3 (n = 33)HPV−1/33 (3%)
HPV-6/111/33 (3%)
HPV-163/33 (9%)16/33 (49%)1/33 (3%)1/33 (3%)
HPV-181/33 (3%)1/33 (3%)
HPV unknown4/33 (12%)4/33 (12%)
% Total24%64%3%9%
SCC (n-10)HPV−
HPV-6/11
HPV-164/8 (50%)4/8 (50%)
HPV-18
HPV unknown
% Total50%50%
cGIN (n = 6)HPV unknown2/14 (14%)1/14 (7%)3/14 (215%)
hcGIN (n = 8)HPV unknown1/14 (7%)3/14 (21.5%4/14 (29%)
% Total21%7%43%29%
Adenocarcinoma (n = 10)HPV unknown3/10 (30%)1/10 (10%)1/103/10
% Total30%10%10%30%