Univariate analysis of prognostic factors
| Variable | HR | 95% CI | p Value |
|---|---|---|---|
| CI, confidence interval; HR, hazard ratio. | |||
| Age (years) | |||
| ⩽65 (n = 51) | 1 | ||
| >65 (n = 84) | 1.130 | 0.737 to 1.735 | 0.5749 |
| Sex | |||
| Male (n = 89) | 1 | ||
| Female (n = 46) | 1.080 | 0.675 to 1.729 | 0.7470 |
| Primary tumour | |||
| ⩽T2 (n = 20) | 1 | ||
| >T2 (n = 11) | 1.846 | 1.018 to 3.350 | 0.0436 |
| Lymph node metastasis | |||
| No (n = 59) | 1 | ||
| Yes (n = 76) | 1.542 | 0.983 to 2.420 | 0.0595 |
| Distant metastasis | |||
| No (n = 128) | 1 | ||
| Yes (n = 7) | 2.438 | 1.049 to 5.665 | 0.0383 |
| Histological grade | |||
| G1 (n = 37) | 1 | ||
| G2 (n = 73) | 1.123 | 0.565 to 2.231 | 0.7401 |
| G3 (n = 25) | 1.280 | 0.676 to 2.425 | 0.4483 |
| Lymphatic invasion | |||
| No (n = 9) | 1 | ||
| Yes (n = 126) | 3.208 | 1.163 to 8.846 | 0.0243 |
| Venous invasion | |||
| No (n = 35) | 1 | ||
| Yes (n = 100) | 1.007 | 0.641 to 1.584 | 0.9745 |
| Perineural invasion | |||
| No (n = 13) | 1 | ||
| Yes (n = 122) | 1.520 | 0.725 to 3.186 | 0.2673 |
| Surgical margins | |||
| Negative (n = 78) | 1 | ||
| Positive (n = 57) | 1.608 | 1.038 to 2.490 | 0.0333 |
| MUC4 expression | |||
| Low (<20%) (n = 114) | 1 | ||
| High (⩾20%) (n = 21) | 2.127 | 1.240 to 3.649 | 0.0061 |
| ErbB2 expression | |||
| Low (<20%) (n = 107) | 1 | ||
| High (⩾20%) (n = 28) | 1.182 | 0.685 to 2.039 | 0.5482 |
| p27 expression | |||
| Low (<20%) (n = 87) | 1 | ||
| High (⩾20%) (n = 48) | 1.469 | 0.955 to 2.258 | 0.0798 |
| MUC1 expression | |||
| Low (<20%) (n = 39) | 1 | ||
| High (⩾20%) (n = 96) | 1.001 | 0.635 to 1.599 | 0.9735 |