Table 1

 Hereditary prostate cancer genes

GeneChromosomal locusPutative functionStatus in prostate cancer
ELAC217pMetal dependent hydrolaseUnknown
RNASEL1qRibonuclease that degrades viral and cellular RNA and can produce 
 >apoptosis on viral infectionDeleted
MSR18pEncodes a macrophage scavenger receptor responsible for cellular 
 >uptake of molecules, including bacterial cell wall productsDeleted
NBSI5pEncodes a protein, nibrin, involved in the processing/repair of DNA 
 >double strand breaks and in cell cycle checkpointsDeleted
CHEK222qUpstream regulator of p53 in the DNA damage signalling pathwayDeleted