Outcome variable | Performance of nm23-H1 (95% CI)* | |||
---|---|---|---|---|
Sensitivity, % | Specificity, % | PPV, % | NPV, % | |
CIN, cervical intraepithelial neoplasia; HR-HPV, high-risk human papillomavirus; NPV, negative predictive value; PPV, positive predictive value. | ||||
*nm23-H1 staining (reduced or strong). | ||||
†Any grade of CIN (squamous cell carcinoma (SCC) cases excluded). | ||||
‡CIN3 cut-off (SCC cases included). | ||||
CIN† | 48.8 (40.4 to 57.3) | 90.0 (71.4 to 100) | 98.5 (95.6 to 100) | 11.5 (4.4 to 18.6) |
CIN3‡ | 68.5 (62.5 to 74.6) | 80.0 (68.9 to 91.1) | 94.0 (90.4 to 97.6) | 35.7 (26.8 to 44.5) |
HR-HPV | 64.4 (57.7 to 71.1) | 52.1 (40.4 to 63.7) | 78.8 (72.6 to 85.2) | 34.5 (25.6 to 43.5) |