Endocardium
| |
Fibrosis | Organised thrombus |
| Healed biopsy site |
| Myocardial infarct |
| Healed acute rejection site |
| Graft procurement injury |
| Adjacent prosthetic device |
| Abnormal blood flow haemodynamics |
| Hypereosinophilic syndrome |
| Mastocytosis |
| Endocardial fibroelastosis |
| Healed myocarditis |
| Cardiomyopathy |
| Drug toxicity |
Ulceration/necrosis | Adjacent prosthetic device |
| Healing biopsy site |
| Hypereosinophilic syndrome |
Myocardium
| |
Hypertrophy | Hypertrophic/dilated cardiomyopathy |
| Pressure/volume overloaded ventricle |
| Storage disorders |
| Primary myopathies (Duchenne’s/Becker’s) |
| Muscular dystrophies (myotonic) |
Fibre disarray | Hypertrophic cardiomyopathy |
| Healed biopsy site |
| Ventricular apex |
| Junction of free wall and interventricular septum |
Interstitium
| |
Fibrosis | Healed biopsy site |
| Myocardial infarct |
| Healed acute rejection site |
| Adjacent prosthetic device |
| Hypereosinophilic syndrome |
| Mastocytosis |
| Healed myocarditis |
| Cardiomyopathy |
| Drug toxicity |
Lymphocytes | Allograft rejection (focal or diffuse) |
| Quilty lesion (A or B) |
| Normal allograft (sparse and diffuse) |
| Myocarditis/dilated cardiomyopathy |
| Post transplant lymphoproliferative disease |
| Lymphoma |
| Leukaemia |
Neutrophils | Bacterial/fungal endocarditis (±necrosis) |
| Fulminant acute allograft rejection |
| Fulminant myocarditis |
| Hypereosinophilic syndrome (+eosinophils) |
| Sepsis |
Eosinophils | Hypereosinophilic syndrome (Loeffler’s) |
| Hypersensitivity (for example, drug) |
| Fulminant allograft rejection |
| Parasitic infection (Chagas) |
Granulomas | Sarcoidosis |
| Amyloidosis |
| Aschoff nodules |
| Foreign body reaction |
| Giant cell myocarditis |
Intramural vessel changes
| Allograft vasculopathy |
| Hypertrophic cardiomyopathy |
| Systemic arterial hypertension |
| Amyloidosis |
| Collagen vascular disorders |
| Mitral valve prolapse |