Marker/stain | Mesothelioma | Adenocarcinoma |
---|---|---|
+, positive; −, negative. | ||
*Positive in a small proportion of non-pulmonary adenocarcinomas. | ||
†Nuclear staining in pulmonary adenocarcinoma and thyroid carcinoma. | ||
‡Positive in some renal, ovarian and endometrioid carcinomas. | ||
§Positive in most renal and urothelial carcinomas. | ||
CEA, Monoclonal carcinoembryonic antigen; TTF-1 thyroid transcription factor-1; WT1, Wilms tumour gene 1; PAS-D, periodic acid-Schiff-D. | ||
Pan-cytokeratin | + | + |
Cytokeratin 5/6 | + | −* |
Calretinin | + | − |
CEA | − | + |
B72.3 | − | + |
TTF-1 | − | +† |
Ber-EP4 | − | + |
D2-40 | + | − |
WT1 | + | −‡ |
Thrombomodulin | + | −§ |
MOC-31 | − | + |
BG-8 | − | + |
CD15 (Leu-M1) | − | + |
Periodic acid-Schiff without diastase | + or − | + |
Periodic acid-Schiff with diastase (PAS-D) | − | + |
Alcian blue | + | +/− |
Alcian blue with hyaluronidase | − | If + without digestion, remains + after digestion |