Microvessel density, vascular endothelial growth factor, Flk-1, cyclooxygenase 2, Ki-67 and p53 expression in B cell lymphomas
| Lymphoma subtype | n Evaluable | Mean (SD) microvessel count/0.57 mm2 | VEGF | Mean (SD) % expression in tumour cells | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean score | Number of cases with different scores | |||||||||||||
| 0 | 1 | 2 | 3 | 4 | 5 | 6 | Flk-1 | COX2 | Ki-67 | p53 | ||||
| COX2, cyclooxygenase 2; DLBCL, diffuse large B cell lymphoma; FL, follicular lymphoma; FL G1&2, FL grade 1&2; MCL, mantle cell lymphoma; SLL/CLL, small lymphocytic lymphoma/chronic lymphocytic leukaemia; VEGF, vascular endothelial growth factor. | ||||||||||||||
| *To simplify statistical assessments, variables ⩾2 were rounded up. | ||||||||||||||
| Primary DLBCL | 109 | 31 (17) | 1.8 | 22 | 36 | 29 | 4 | 12 | 5 | 1 | 4 (9) | 1.4 (4) | 45 (22) | 8 (19) |
| Secondary DLBCL | 18 | 29 (19) | 1.8 | 5* | 2 | 8 | 1 | 1 | 1 | 0 | 4 (10) | 0.6 (1.6) | 35 (24) | 12 (27) |
| MCL | 19 | 19 (7) | 1.2 | 5 | 8 | 4 | 2 | 0 | 0 | 0 | 1.5 (2) | 0.5 (2) | 17 (12) | 1.3 (5) |
| FL G3 | 15 | 22 (11) | 0.7 | 8 | 4 | 3 | 0 | 0 | 0 | 0 | 1.3 (2.3) | 0.0 (0.0) | 18 (10) | 1.2 (2) |
| FL G1&2 | 67 | 22 (8) | 0.9 | 31 | 20 | 16 | 0 | 0 | 0 | 0 | 0.6 (2) | 0.07 (0.6) | 8 (5) | 0.06 (0.3) |
| SLL/CLL | 38 | 19 (12) | 1.1 | 11 | 12 | 14 | 1 | 0 | 0 | 0 | 0.9 (3) | 0.0 (0.0) | 9 (13) | 0.5 (3) |
| Differences between diagnosis groups | p<0.001 | p<0.001 | p = 0.017 | p = 0.013 | p<0.001 | p = 0.01 | ||||||||