Diagnostic marker | ROC analysis for tumour grade | ||
---|---|---|---|
AUC estimate (95% CI) | Area under the ROC curve | Mann–Whitney test (p value) | |
AUC, area under the receiver operating characteristic (ROC) curve; ERα, oestrogen receptor α; IRS-1, insulin receptor substrate 1. | |||
The analysis was performed with ROC curves, as described in Materials and methods section. The AUC describes the value of nuclear IRS-1 or ERα to discriminate between G2 and G3 tumours. AUC estimate reports the CIs considering an error of 5%. The statistical significance was evaluated by Mann–Whitney U test for an area = 0.5. | |||
Ductal carcinoma | |||
ERα | 71.4 (41.9 to 91.4) | 0.809 | 0.001 |
IRS-1 | 78.6 (49.2 to 95.1) | 0.778 | 0.001 |
Lobular carcinoma | |||
ERα | 80.0 (28.8 to 96.7) | 0.817 | 0.02 |
IRS-1 | 60.0 (15.4 to 93.5) | 0.533 | 0.85 |