Table 1

Clinicopathological data in the colorectal cancers

Causative gene	Patient number	Sex	Age	Tumour location	pTNM	Tumour differentiation	Expanding growth pattern	Morphological heterogeneity	Crohn-like reaction	Tumour infiltrating lymphocytes	Peritumoural lymphocytes	p53 staining	β-catenin cytoplasmic staining	β-catenin nuclear staining
NE, not evaluated; *medullary carcinoma; †mucinous carcinoma; ‡microsatellite stable.
MSH2	C1.1	M	78	Proximal	pT3N2	Poor	+	+	+	+	–	–	+	–
	C1.3	M	78	Proximal	pT1sm1	Moderate	NE	+	NE	NE	+	–	–	–
	C2.1	M	60	Proximal	pT3N0	Undiff*	+	–	–	+	+	–	–	–
	C2.4	M	67	Proximal	pT2NX	Poor	+	+	–	+	–	–	+	–
	C2.5	M	67	Proximal	pT2NX	Poor	+	+	–	+	+	+	+	–
	C2.6	M	67	Proximal	pT2NX	Moderate	+	–	+	–	+	–	–	–
	C3.1	F	44	Proximal	pT3N0	Poor†	+	–	–	–	–	+	+	–
	C3.2	F	50	Rectal	pT2N0	Moderate	+	–	+	+	+	+	+	–
	C4	M	64	Rectal	pT4aNX	Moderate	–	–	–	–	–	–	+	–
	C5	M	40	Rectal	NE (biopsy)	Moderate	NE	+	NE	–	NE	+	+	–
	C6.1	F	42	Rectal	pT2N0	Moderate	–	+	–	–	–	–	+	–
	C6.2	F	52	Proximal	pT3N0	Undiff*	+	–	+	+	+	–	+	+
	C7.1	M	40	Proximal	pT1sm1	Moderate	NE	–	NE	NE	+	+	+	–
	C7.2‡	M	40	Proximal	pT3N0	Moderate	+	–	+	+	+	–	+	–
	C8.3	F	62	Proximal	pT3N0	Undiff*	+	–	+	+	+	–	+	–
	C9	M	48	Distal	pT3N2	Moderate	–	+	+	–	–	–	+	–
	C11.3	F	63	Distal	pT4aN0	Moderate	–	+	+	–	+	–	+	–
	C12	M	48	Rectal	pT3N1	Poor	–	–	–	+	+	+	+	+
	C14	M	47	Proximal	pT3N0	Moderate	+	+	–	–	+	–	+	–
	C15	M	39	Rectal	pT1sm1	Moderate	NE	–	NE	NE	+	+	+	–
	C16.1	M	61	Distal	pT2N0	Moderate	+	+	+	–	+	–	+	–
	C16.2	M	61	Proximal	pT3N0	Moderate	+	–	+	+	+	–	+	–
MLH1	L1.1	M	53	Proximal	pT3N0	Moderate	+	–	–	+	+	–	+	–
	L2.1	F	47	Proximal	pT3N0	Poor	+	+	–	–	+	+	–	–
	L3	M	45	Proximal	pT3N0	Poor	–	+	–	+	+	–	+	+
	L4	F	23	Proximal	pT3N2	Poor	–	+	–	+	+	+	–	–
	L5	M	38	Rectal	pT3N0	Moderate	–	+	–	+	+	–	+	+
	L6	M	55	Proximal	pT3N0	Poor	+	+	–	+	+	–	–	–
	L8	M	61	Proximal	pT3N1	Poor	+	+	+	+	+	–	+	–