Histopathological criteria to distinguish prostatic lesions with ductal morphology
| Morphological criteria | PIN | Intraductal carcinoma | Ductal carcinoma |
|---|---|---|---|
| PIN, prostatic intraepithelial neoplasm. | |||
| Size of glands/ducts | Normal—distended | Markedly distended | Large duct-like structures |
| Lumen spanning | Occasional | Required | Yes |
| Basal cells | Yes | Yes, disrupted | Rarely |
| Columnar | No | Occasionally | Yes |
| Papillary structures | No | No | Occasionally |
| Cribriform pattern | Yes | Frequently | Frequently |
| Central necrosis | No | Occasionally | Occasionally |
| Severe nuclear atypia | Rare | Occasionally | Occasionally |
| Maturation effect | Yes | Occasionally | No |
| Stromal haemosiderin | No | No | Occasionally |