Correlation with survival | Significance | Hazard ratio | 95% CI | |
Univariate analysis (independent of cyclin E) | Residual disease present at time of surgery | p = 0.001 | 16.36 | 5.84 to 45.89 |
Lymph node metastases | p = 0.006 | 6.00 | 1.40 to 25.75 | |
T-stage | None | – | – | |
Multivariate analysis (inclusion of cyclin E) | Residual disease present at time of surgery | p = 0.001 | 21.38 | 6.83 to 66.96 |
Cyclin E negative staining (C-terminal antibody) | p = 0.001 | 5.63 | 2.05 to 15.46 | |
Lymph node metastases | p = 0.002 | 12.09 | 2.44 to 59.93 | |
T-stage | None | – | – |