Child or young adult | | Middle-aged or older adult |
Mass in lung or soft tissue of abdomen, pelvis, or retroperitoneum | | Mass in skin or subcutis, lymph node, spleen, or bladder |
Diffuse inflammatory infiltrate with prominent plasma cells | | Patchy, predominantly lymphocytic inflammatory infiltrate |
Mild nuclear atypia including scattered ganglion-like cells | | Moderate to severe nuclear atypia with hyperchromasia |
Low mitotic rate without atypical forms | | Atypical mitoses |
ALK positivity by immunohistochemistry or ALK gene rearrangement | | Necrosis |