Table 2 Correlations between forkhead box A1 (FOXA1) expression, clinicopathological parameters and immunohistochemical markers in 245 invasive breast carcinomas
ParameterNo.Sub-groupFOXA1neg(%)FOXA1pos(%)Correlationp value
Size182T119 (20)79 (80)0.1560*
T221 (30)50 (70)
T35 (38)8 (62)
Grade180I2 (12)14 (88)Negative0.0327*
II8 (15)47 (85)
III34 (31)75 (69)
Type181IDC32 (25)97 (75)0.6177*
ILC5 (17)25 (83)
Other6 (27)16 (73)
LVI18219 (28)48 (72)0.3702**
+25 (22)90 (78)
LN metastasis17717 (27)47 (73)0.7197**
+27 (24)86 (76)
ER18324 (73)9 (27)Positive<0.0001**
+20 (13)130 (87)
PR18323 (50)23 (50)Positive<0.0001**
+21 (15)116 (85)
HER218339 (25)119 (75)0.8020**
+5 (20)20 (80)
EGFR18432 (19)135 (81)Negative<0.0001**
+13 (76)4 (24)
CK1418231 (19)135 (81)Negative<0.0001**
+13 (81)3 (19)
CK5/617632 (20)127 (80)Negative0.0002**
+11 (65)6 (35)
CK1718230 (18)133 (82)Negative0.0001**
+14 (74)5 (26)
p5318221 (16)107 (84)Negative0.0001**
+24 (44)30 (56)
MIB1180<10%10 (13)67 (87)Negative<0.0001*
10–30%19 (24)60 (76)
>30%16 (67)8 (33)
Cyclin D1182Low10 (50)10 (50)Positive0.0012*
Intermediate12 (36)21 (64)
High22 (17)107 (83)
Topo2A180Low14 (17)67 (83)0.0550**
High30 (30)69 (70)
Nielsen group176Basal18 (82)4 (18)Negative0.0001*
Luminal18 (14)112 (86)Positive
HER-25 (21)19 (79)Positive
  • Subgroups were defined according to the definition described by Nielsen et al.6

  • 2 test; **Fisher’s exact test.

  • FOXA1pos, high level of FOXA1 expression (score greater than 3); FOXA1neg, low level of FOXA1 expression (score 3 or less); CK, cytokeratin; ER, oestrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor receptor 2; LN metastasis, lymph node metastasis; LVI, lymphovascular invasion; Topo2A, topoisomerase IIα; IDC, infiltrating ductal carcinoma; ILC, infiltrating lobular carcinoma.