| Factor | Total no. | ANA+n = 187(41.8%) | ANA−n = 260(58.2%) | p Value |
| Sex, female (%) | 184 | 88 (47.8) | 96 (37.6) | 0.020 |
| Age, years | 447 | 53.5 (10.4)* | 49.8 (10.9)* | <0.001 |
| AST, IU/l | 447 | 118.9 (65.8)* | 99.3 (62.3)* | <0.001† |
| ALT, IU/l | 447 | 177.8 (124.4)* | 156.3 (109.8)* | 0.005† |
| HCV genotype | 0.069 | |||
| 1b (%) | 219 | 82 (43.9) | 137 (52.7) | |
| HCV RNA, log IU/ml | 447 | 5.2 (0.9)* | 5.4 (0.9)* | 0.008 |
| Necroinflammatory score | 447 | 5.1 (2.4)* | 4.8 (2.5)* | 0.164† |
| Fibrosis score | 447 | 2.0 (1.3)* | 1.5 (1.1)* | <0.001† |
| F0–2 (%) | 328 | 118 (63.1) | 210 (80.8) | <0.001 |
| F3–4 (%) | 119 | 69 (36.9) | 50 (19.2) | <0.001 |
*Values are means (SD), unless otherwise indicated.
†p value obtained using non-parametric Mann–Whitney test.
HCV, hepatitis C virus; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ANA+, ANA positive; ANA−, ANA negative.