Table 2 Univariate analysis by the Cox proportional hazards regression analysis for overall survival (OS) and disease-free survival rate (DFS)

Variable	OS		DFS
Variable	HR (95% CI)	p Value	HR (95% CI)	p Value
Tumour size	4.900 (1.320–18.182)	0.018*	2.300 (1.179–4.488)	0.015*
Histologic grade	28.646 (0.063–13 039.5)	0.283	5.066 (1.205–21.304)	0.027*
Tumour invasiveness	2.216 (0.596–8.233)	0.235	1.424 (0.709–2.859)	0.320
HIF-1α	1.257 (0.398–3.966)	0.696	2.503 (1.226–5.112)	0.012*
TAM	1.011 (0.965–1.059)	0.657	1.031 (1.006–1.056)	0.015*
VEGF	1.593 (0.431–5.894)	0.485	1.630 (0.762–3.485)	0.208
MVD	0.970 (0.904–1.040)	0.387	0.986 (0.950–1.024)	0.464

*p<0.05 indicates statistical significance.
HIF, hypoxia-inducible factor; HR, hazard ratio; MVD, microvessel density; TAM, tumour-associated macrophage; VEGF, vascular endothelial growth factor.