| Gross architectural distortion (modified from METAVIR system10) | | 0 | | No definite fibrosis |
| 1 | | Minimal fibrosis (no septa or rare thin septum) |
| 2 | | Mild fibrosis (occasional thin septa) |
| 3 | | Moderate fibrosis (moderate thin septa; up to incomplete cirrhosis) |
| 4 | | Cirrhosis definite or probable |
| | | | |
| Sinusoidal fibrosis (modified from published system11) | | 0 | | No sinusoidal fibrosis |
| 1 | | Sinusoidal fibrosis present in <1/3 sinusoids |
| 2 | | Sinusoidal fibrosis present in 1/3–2/3 sinusoids |
| 3 | | Sinusoidal fibrosis affecting >2/3 sinusoids |
| | | | |
| Orcein positivity (gross architecture or sinusoidal fibrosis, possibly reflecting matrix maturity12) | | 0 | | None of the fibrotic matrix is orcein positive |
| 1 | | <1/3 fibrotic matrix is orcein positive |
| 2 | | 1/3–2/3 of fibrotic matrix is orcein positive |
| 3 | | >2/3 fibrotic matrix is orcein positive |
| | | | |
| Sinusoidal dilatation (previously published system13) | | 0 | | No sinusoidal dilatation |
| 1 | | <1/3 sinusoids dilated |
| 2 | | 1/3–2/3 sinusoids dilated |
| 3 | | >2/3 sinusoids dilated |
| | | | |
| Bile ductular reaction (previously published system14) | | 0 | | No ductular reaction |
| 1 | | Mild ductular reaction |
| 2 | | Moderate ductular reaction |
| 3 | | Severe ductular reaction |
| | | | |
| Cholestasis | | 0 | | No cholestasis |
| 1 | | Cholestasis present |
| | | | |
| Iron deposition | | 0 | | No iron deposition |
| 1 | | Stainable iron present |
| | | | |
| Hepatocellular damage | | 0 | | No evidence of hepatocyte damage |
| 1 | | Hepatocyte ballooning, necrosis or apoptosis |
| | | | |
| Inflammation | | 0 | | No lobular inflammation |
| 1 | | Lobular inflammation |