Table 2 Disease associations, molecular and cellular functions, physiological systems and canonical pathway associations for differentially expressed genes in 55 patients with chronic fatigue syndrome
Combined*Subtype 1Subtype 2Subtype 3Subtype 4Subtype 5Subtype 6Subtype 7
DiseasesHaematological (22)Neurological (18)Neurological (21)Neurological (16)Neurological (11)Neurological (21)Neurological (25)Neurological (24)
Immunological (14)Haematological (14)Haematological (18)Haematological (10)Haematological (10)Haematological (18)Haematological (20)Haematological (23)
Cancer (31)Cancer (21)Inflammatory (11)Cancer (15)Immunological (7)Immunological (13)Immunological (17)Immunological (17)
Dermatological (3)Cardiovascular (6)Cancer (26)Endocrine system (5)Cancer (14)Cancer (26)Inflammatory (14)Cancer (27)
Endocrine system (9)Inflammatory (6)Immunological (15)Metabolic (4)Organismal injury (8)Inflammatory (26)Cancer (26)Inflammatory (12)
Molecular and cellular functionsCellular development (26)Cell signalling (26)Cell signalling (31)Gene expression (16)Cellular development (10)Cell death (30)Cell signalling (33)Cell signalling (33)
Cell death (33)Cellular assembly and organisation (11)Cellular growth and proliferation (24)Cell death (15)Cell death (13)Cell death (25)Cellular growth and proliferation (26)Cell death (27)
Gene expression (31)Cellular compromise (6)Gene expression (27)Cell signalling (16)Cell signalling (14)Cellular movement (17)Cellular development (20)Cellular movement (20)
Cellular growth and proliferation (31)Cell death (20)Cellular movement (18)Cellular movement (10)Cellular growth and proliferation (12)Gene expression (25)Gene expression (27)Cellular development (21)
Cellular assembly and organisation (15)Cellular growth and proliferation (18)Cell death (25)Protein synthesis (6)Gene expression (10)Cellular development (18)Cell death (25)Gene expression (27)
Physiological system development and functionHaematological system development and function (22)Nervous system development and function (15)Immune response (17)Haematological system development and function (7)Haematological system development and function (8)Organismal survival (13)Haematological system development and function (17)Tissue morphology (18)
Immune and lymphatic system development and function (18)Organismal survival (9)Organismal survival (12)Immune response (8)Tissue morphology (10)Tissue morphology (14)Immune and lymphatic system development and function (16)Haematological system development and function (16)
Tissue morphology (18)Haematological system development and function (11)Haematological system development and function (15)Organismal survival (8)Organismal survival (9)Haematological system development and function (16)Tissue morphology (16)Immune and lymphatic system development and function (16)
Organismal survival (17)Immune response (13)Tissue morphology (13)Tissue morphology (9)Immune and lymphatic system development and function (6)Immune and lymphatic system development and function (13)Organismal survival (15)Organismal survival (16)
Immune response (20)Tissue morphology (9)Nervous system development and function (15)Nervous system development and function (12)Immune response (8)Immune response (17)Immune response (19)Immune response (19)
Top canonical pathwaysInterferon signalling (2)Actin cytoskeleton signalling (6)IL6 signalling (5)Axonal guidance signalling (5)Insulin receptor signalling (3)Acute-phase response signalling (6)Acute-phase response signalling (6)Ephrin receptor signalling (5)
IL6 signalling (6)Ephrin receptor signalling (5)Actin cytoskeleton signalling (6)Actin cytoskeleton signalling (4)B cell receptor signalling (3)IL6 signalling (5)IL6 signalling (5)Axonal guidance signalling (6)
EGF signalling (3)ERK/MAPK signalling (5)Acute-phase response signalling (5)Hepatic fibrosis/stellate cell activation (3)Acute-phase response signalling (3)ERK/MAPK signalling (6)ERK/MAPK signalling (6)Oestrogen receptor signalling (4)
IL2 signalling (3)IL6 signalling (4)Ephrin receptor signalling (5)Insulin receptor signalling (3)ERK/MAPK signalling (3)Axonal guidance signalling (7)Insulin receptor signalling (5)Actin cytoskeleton signalling (5)
PPAR signalling (5)Axonal guidance signalling (6)ERK/MAPK signalling (5)Acute-phase response signallingActin cytoskeleton signalling (3)Actin cytoskeleton signalling (6)B cell receptor signalling (5)Hepatic fibrosis and stellate cell activation (4)
  • Results are presented for the group as a whole and for each of the seven genomically derived subtypes.

  • *Kerr et al (2008).6

  • IL, interleukin; ERK, extracellular signal regulated kinase; MAPK, mitogen-activated protein kinase; PPAR, peroxisome proliferator-activated receptor; EGF, epidermal growth factor.