Combined* | Subtype 1 | Subtype 2 | Subtype 3 | Subtype 4 | Subtype 5 | Subtype 6 | Subtype 7 | |
Diseases | Haematological (22) | Neurological (18) | Neurological (21) | Neurological (16) | Neurological (11) | Neurological (21) | Neurological (25) | Neurological (24) |
Immunological (14) | Haematological (14) | Haematological (18) | Haematological (10) | Haematological (10) | Haematological (18) | Haematological (20) | Haematological (23) | |
Cancer (31) | Cancer (21) | Inflammatory (11) | Cancer (15) | Immunological (7) | Immunological (13) | Immunological (17) | Immunological (17) | |
Dermatological (3) | Cardiovascular (6) | Cancer (26) | Endocrine system (5) | Cancer (14) | Cancer (26) | Inflammatory (14) | Cancer (27) | |
Endocrine system (9) | Inflammatory (6) | Immunological (15) | Metabolic (4) | Organismal injury (8) | Inflammatory (26) | Cancer (26) | Inflammatory (12) | |
Molecular and cellular functions | Cellular development (26) | Cell signalling (26) | Cell signalling (31) | Gene expression (16) | Cellular development (10) | Cell death (30) | Cell signalling (33) | Cell signalling (33) |
Cell death (33) | Cellular assembly and organisation (11) | Cellular growth and proliferation (24) | Cell death (15) | Cell death (13) | Cell death (25) | Cellular growth and proliferation (26) | Cell death (27) | |
Gene expression (31) | Cellular compromise (6) | Gene expression (27) | Cell signalling (16) | Cell signalling (14) | Cellular movement (17) | Cellular development (20) | Cellular movement (20) | |
Cellular growth and proliferation (31) | Cell death (20) | Cellular movement (18) | Cellular movement (10) | Cellular growth and proliferation (12) | Gene expression (25) | Gene expression (27) | Cellular development (21) | |
Cellular assembly and organisation (15) | Cellular growth and proliferation (18) | Cell death (25) | Protein synthesis (6) | Gene expression (10) | Cellular development (18) | Cell death (25) | Gene expression (27) | |
Physiological system development and function | Haematological system development and function (22) | Nervous system development and function (15) | Immune response (17) | Haematological system development and function (7) | Haematological system development and function (8) | Organismal survival (13) | Haematological system development and function (17) | Tissue morphology (18) |
Immune and lymphatic system development and function (18) | Organismal survival (9) | Organismal survival (12) | Immune response (8) | Tissue morphology (10) | Tissue morphology (14) | Immune and lymphatic system development and function (16) | Haematological system development and function (16) | |
Tissue morphology (18) | Haematological system development and function (11) | Haematological system development and function (15) | Organismal survival (8) | Organismal survival (9) | Haematological system development and function (16) | Tissue morphology (16) | Immune and lymphatic system development and function (16) | |
Organismal survival (17) | Immune response (13) | Tissue morphology (13) | Tissue morphology (9) | Immune and lymphatic system development and function (6) | Immune and lymphatic system development and function (13) | Organismal survival (15) | Organismal survival (16) | |
Immune response (20) | Tissue morphology (9) | Nervous system development and function (15) | Nervous system development and function (12) | Immune response (8) | Immune response (17) | Immune response (19) | Immune response (19) | |
Top canonical pathways | Interferon signalling (2) | Actin cytoskeleton signalling (6) | IL6 signalling (5) | Axonal guidance signalling (5) | Insulin receptor signalling (3) | Acute-phase response signalling (6) | Acute-phase response signalling (6) | Ephrin receptor signalling (5) |
IL6 signalling (6) | Ephrin receptor signalling (5) | Actin cytoskeleton signalling (6) | Actin cytoskeleton signalling (4) | B cell receptor signalling (3) | IL6 signalling (5) | IL6 signalling (5) | Axonal guidance signalling (6) | |
EGF signalling (3) | ERK/MAPK signalling (5) | Acute-phase response signalling (5) | Hepatic fibrosis/stellate cell activation (3) | Acute-phase response signalling (3) | ERK/MAPK signalling (6) | ERK/MAPK signalling (6) | Oestrogen receptor signalling (4) | |
IL2 signalling (3) | IL6 signalling (4) | Ephrin receptor signalling (5) | Insulin receptor signalling (3) | ERK/MAPK signalling (3) | Axonal guidance signalling (7) | Insulin receptor signalling (5) | Actin cytoskeleton signalling (5) | |
PPAR signalling (5) | Axonal guidance signalling (6) | ERK/MAPK signalling (5) | Acute-phase response signalling | Actin cytoskeleton signalling (3) | Actin cytoskeleton signalling (6) | B cell receptor signalling (5) | Hepatic fibrosis and stellate cell activation (4) |
Results are presented for the group as a whole and for each of the seven genomically derived subtypes.
*Kerr et al (2008).6
IL, interleukin; ERK, extracellular signal regulated kinase; MAPK, mitogen-activated protein kinase; PPAR, peroxisome proliferator-activated receptor; EGF, epidermal growth factor.