Table 2 Correlation of TROP2 with conventional clinicopathological parameters in patients with intestinal-type and diffuse-type gastric cancer
Total patientsp ValueTROP2 overexpressionp Value
NoYes
nDFSOSn (%)n (%)
Intestinal-type carcinoma
Sex
    Male630.600.5323 (26)40 (45)0.32
    Female2512 (14)13 (15)
Histological grade
    Well30.510.062 (2)1 (1)0.48
    Moderate3214 (16)18 (20)
    Poor5319 (22)34 (39)
Depth of wall invasion (T stage)
    pT1160.0010.016 (7)10 (11)0.95
    pT25220 (23)32 (36)
    pT3188 (9)10 (11)
    pT421 (1)1 (1)
Lymph node metastasis
    No360.0010.0112 (14)24 (27)0.30
    Yes5223 (26)29 (33)
Distant metastasis
    No790.0030.00133 (38)46 (52)0.25
    Yes92 (2)7 (8)
Resection margin
    R0 vs.850.0010.0335 (41)50 (59)0.15
    R1+R233 (100)
Stage (UICC)
    I320.010.4011 (13)21 (24)0.43
    II+III+IV5624 (27)32 (36)
Diffuse-type carcinoma
Sex
    Male70.480.814 (25)3 (19)0.37
    Female97 (44)2 (12)
Histological grade
    Well10.130.151 (6)5 (31)0.48
    Moderate1510 (63)
    Poor
Depth of wall invasion (T stage)
    pT10.0010.130.01
    pT288 (50)
    pT372 (12)5 (31)
    pT411 (6)
Lymph node metastasis
    No100.790.618 (50)2 (12)0.21
    Yes63 (19)3 (19)
Distant metastasis
    No150.0010.0510 (63)5 (31)0.48
    Yes11 (6)
Resection margin
    R0 vs.120.680.85930.35
    R1+R2422
Stage (UICC)NFNF
    I55 (31)5 (31)0.06
    II+III+IV116 (38)
  • DFS, disease-free survival; OS, overall survival; NF, not feasible.