Table 3

Common cytogenetic alterations in paediatric renal tumours32 33 34

TumourType of abnormality
Rhabdoid tumour of kidney70% show mutation or deletion of both copies of the hSNF5/INI1 gene that map to chromosome band 22q11.2
Cellular congenital mesoblastic nephromat (12; 15) (p13, q25)/ETV6/NTRK3 gene fusion
NeuroblastomaN myc amplification in 30–40%
Primitive neuroectodermal tumour/Ewing sarcomat(11;22) or EWS-FLI1 is the commonest seen in 85%; t(21;22), t(7;22), t(17;22), and t (2;22) are observed in remainder
Synovial sarcoma90% show t(X;18)(p11.2;q11.2)
Renal cell carcinomat(X; 17) (p11.2; q21) and t(X; 1) (p11.2; p34)/Xp11.2 translocations/TFE3 gene fusions