Clinical and pathological data, histological diagnoses, morphology and immunohistochemical expression in the WDLPS and DDLPS cases
Case no. | Sex/age | Localisation/size (cm) | Diagnosis | Subtype or dedifferentiated area morphology | IHC MDM2/CDK4 | MDM2/CDK4 staining pattern | Observations |
1 | M/65 | Retroperitoneum/17 | WDLPS | Lipoma-like | +/+ | 1/1 | Stroma with myxoid areas |
2 | M/76 | Retroperitoneum/15 | WDLPS | Esclerosing | +/+ | 2/1 | |
4 | M/68 | Thorax/7 | WDLPS | Lipoma-like | +/− | 1/4 | |
5 | M/63 | Retroperitoneum/31 | WDLPS | Esclerosing | +/− | 1/3 | |
9 | M/NI | Retroperitoneum/44 | WDLPS | Esclerosing | +/− | 2/4 | |
10 | M/59 | Retroperitoneum/10 | DDLPS | UPS | +/+ | 1/1 | |
13 | M/35 | Retroperitoneum/17 | DDLPS | UPS | +/+ | 1/1 | |
14 | M/72 | Cervical/BI | WDLPS | Lipoma-like | +/− | 1/4 | |
16 | M/66 | Thigh/6 | WDLPS | Lipoma-like | +/+ | 1/1 | Hibernomatous-like cells |
17 | F/48 | Retroperitoneum/25 | WDLPS | Esclerosing | +/+ | 1/1 | |
18 | M/58 | Retroperitoneum/19 | WDLPS | Lipoma-like | +/+ | 1/1 | Floret-like cells |
19 | F/73 | Thigh/33 | DDLPS | UPS | −/− | 3/4 | |
22 | F/32 | Leg/14 | WDLPS | Lipoma-like | +/− | 1/4 | |
27 | M/77 | Retroperitoneum/12 | WDLPS | Esclerosing | +/+ | 1/1 | |
28 | F/55 | Retroperitoneum/11 | DDLPS | UPS | +/+ | 1/1 | |
29 | F/73 | Retroperitoneum/24 | DDLPS | LG-SCS | +/+ | 1/1 | |
32 | NI/NI | Knee/IB | WDLPS | Esclerosing | +/+ | 1/1 | |
38 | NI/NI | NI/NI | WDLPS | Esclerosing | +/+ | 1/1 | |
50 | F/49 | Thigh/7 | WDLPS | Lipoma-like | +/− | 1/4 | |
51 | M/58 | Thigh/10 | DDLPS | UPS | +/− | 1/4 | |
68 | F/80 | Pelvis/22 | DDLPS | Myx-UPS | +/− | 1/4 | |
70 | F/80 | Retroperitoneum/35 | DDLPS | MXFBS-like | +/+ | 1/1 | |
73 | M/65 | Retroperitoneum/15 | DDLPS | UPS | +/+ | 1/1 | |
75 | M/70 | Retroperitoneum/40 | WDLPS | Esclerosing | +/+ | 1/1 | |
106 | F/49 | Arm/15 | WDLPS | Lipoma-like | +/+ | 1/2 | |
112 | M/56 | Scalp/5 | WDLPS | Esclerosing | +/+ | 1/1 | |
126 | M/54 | Cervical/10 | WDLPS | Spindle cell | +/+ | 1/1 | Stroma with myxoid areas |
127 | F/38 | Retroperitoneum/6 | DDLPS | Neural-like nodules | +/+ | 1/1 | With metaplastic bone |
129 | M/47 | Dorsal/7 | WDLPS | Lipoma-like | +/+ | 1/1 |
Staining pattern: 1, diffuse positivity (>30% of cells were immunoreactive); 2, moderate positivity (10–29% of cells were immunoreactive); 3, focal positivity (<10% of cells were immunoreactive); 4, negative (no cell was immunoreactive).
M, male; F, female; IB, incisional biopsy; NI, non-informed; WDLPS, well differentiated liposarcoma; DDLPS, dedifferentiated liposarcoma; UPS, undifferentiated pleomorphic sarcoma; LG-SCS, low grade spindle cell sarcoma; Myx-UPS, myxoid undifferentiated pleomorphic sarcoma; MXFBS, mixofibrosarcoma.